The RelB/p52 heterodimer is the product of NF- [kappa]B signaling pathways, referred to as the non- canonical pathways, which involve processing of the precursor protein p100 into p52. However, whether the RelB /p52 heterodimer is generated from the p100/RelB complex observed in uninduced ...
Product Name:ANTI-NF KAPPA B P52 Synonyms:ANTI-NF KAPPA B P52;ANTI-NF-KAPPAB (P52) (AB-1), HUMAN;ANTI-NF-KAPPAB (P52) (AB-1) RABBIT PAB;ANTI-NFKB2;ANTI-NUCLEAR FACTOR KAPPAB;ANTI-NUCLEAR FACTOR KAPPA-B (AB-1) RABBIT PAB;ANTI-NUCLEAR FACTOR KAPPAB (P52) (AB-1), HUMAN;ANTI-...
在哺乳动物中该家族有5种蛋白,分别为:RelA(p65),RelB,c-Rel,NF-κB1(p50)和NF-κB2(p52)。它们的N端有着高度保守Rel同源区(Rel homology region,RHR),RHR由N端结构域(N-terminal domain,NTD)和C端结构域(C-terminal domain,CTD)连接而成,在CTD上有一个核定位区域(nuclear-localization sequence, NLS)...
Tyr-66 is conserved in RHDcontaining NF-B family members, including p65, p50, p52, p100, p105, and c-Rel, but Tyr-152 is unique to p65. The anti-NTyr antibody detected a weak band of p50 (Fig. 2), ...Huguet C, Crepieux P, Laudet V. Rel/NF-kappa B transcription factors ...
This page is a summary of:The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner., Molecular and Cellular Biology, June 1993, ASM Journals, ...
我做的就是NF-KB p50在耳蜗的表达，后来也做了p65，我发现在耳蜗p50的表达比p65多，这两种抗体中杉都能买到，我觉的p65/p50二聚体是表达最多的NF-KB抗体，应该都做一下。在一篇文献上看过这样一句“虽然P65和p50是NF-κB的两个重要的亚单位，p50又不同于p65，p50的C末端没有反式激活域，所以...
Constitutively active forms consist of dimers of p50 and p52 with RelB and c-Rel =-=(39, 41)-=-. Although we have demonstrated that RelA is involved in the regulation of the ALV enhancer, it is possible that other Rel factors may also interact with VBP. The developmental expression and...
Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution. EMBO J. 1997, 16, 7078–7090. [Google Scholar] [CrossRef] Milanovic, M.; Kracht, M.; Schmitz, M.L. The cytokine-induced conformational switch of nuclear factor κB p65 is mediated by p65 phosphorylation. ...
The transcription factor NF-κB family, including p65 (RelA), RelB, c-Rel, p52, and p50, has crucial roles in innate immune response, inflammation, and cancer initiation and progression [15]. To confirm whether MMPP can suppress the NF-κB pathway, we sequentially identified whether IKK, I...