Interferon-gamma (IFN-gamma) is a pleiotropic lymphokine whose production is restricted to activated T cells and NK cells. Along with other cytokines, IFN-gamma gene expression is inhibited by the immunosuppressant cyclosporin A. We have previously identified an intronic enhancer region (C3) of ...
IFNalpha/beta promotes cell survival by activating NF-kappaB through phosphatidylinositol-3 kinase and Akt p pThe potential mechanisms of action of ozone therapy are reviewed in this paper. The therapeutic efficacy of ozone therapy may be partly due the controll... CH Yang,A Murti,SR Pfeffer,...
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An essential role for NF-kappa B in IL-18-induced IFN-gamma expression in KG-1 cells. IL-18 is a multifunctional cytokine playing various regulatory roles in the immune system including induced cytokine production. As a part of our ongoing s... H Kojima,Y Aizawa,Y Yanai,... - 《Journa...
www.nature.com/scientificreports OPEN Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions received: 11 October 2016 accepted: 13 February 2017 Published: 20 March 2017 Chen Zhang1, Hui Jiang2, Pin Wang3, Heng Liu3 & Xiulian Sun4 ...
CD4+ T cells from p50-/- mice failed to induce Gata3 expression under TH2-differentiating conditions but showed unimpaired T-bet expression and interferon gamma (IFN-gamma) production under TH1-differentiating conditions. Inhibition of NF-kappa B activity prevented GATA-3 expression and TH2 ...
Introduction: Inflammatory bowel disease (IBD) is associated with altered apoptosis and increased levels of Th1 cytokines (IL-12, TNF-α, and IFN-γ). Defects in Stat6, a signal transduction molecule, may lead to increased Th1 effects. We have cell lines derived from IBD patients that expres...
16. Bito T, Roy S, Sen CK, Shirakawa T, Gotoh A, Ueda M, Ichihashi M, Packer L (2002) Flavonoids differentially regulate IFN-γ-induced ICAM-1 expression in human keratinocytes: molecular mechanisms of action. FEBS Lett 520:145–152 Article PubMed CAS Google Scholar 17. Wang YH, Wang...
LIGHT and IFN- synergistically reduced MIN6 and primary islet cells viability; decreased cell viability was due to apoptosis, as demonstrated by a significant increase in Annexin V+ cell percentage, detected by flow cytometry. In addition to marked increases in cytochrome c release and NF-B ...