Beyaert, Karin and colleagues discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-[kappa]B pathway and the NLRP3 inflammasome.doi:10.1038/ni.3772Inna S Afonina...
Limiting inflammation[mdash]the negative regulation of NF-[kappa]B and the NLRP3 inflammasome Beyaert, Karin and colleagues discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-[kappa]B pathway...
The nuclear factor-kappa B (NF-κB) pathway is the most widely studied inflammatory signaling pathway within acinar cells, and is correlated with a greater severity of acute pancreatitis [8]. NF-κB activation and trypsinogen activation are independent early events and play different roles in the ...
Indomethacin inhabits the NLRP3 inflammasome pathway and protects severe acute pancreatitis in mice Biochem. Biophys. Res. Commun. (2017)View more references Cited by (3) Triglycerides: A Sensitizer but Not a Trigger for Hypertriglyceridemic Acute Pancreatitis 2024, Digestive Diseases and Sciences Inv...
Meanwhile, alpha-Cyperone could downregulate NF-kappa B and NLRP3 signaling pathways. Finally, we found alpha-Cyperone could up-regulate the expression of SIRT1 and SIRT1 inhibitor could reverse the protective effects of alpha-Cyperone on ALI. In conclusion, alpha-Cyperone showed the protective ...
NLRP3 inflammasomesAims: Fc gamma receptor I (Fc gamma RI/CD64) that is restrictedly expressed on monocytes and macrophages, acts as the single high-affinity receptor of immunoglobulin G (IgG) in human. The expression of Fc gamma RI is positively correlated with immune inflammation. The ...
NaB activated the COX-2/Nrf2/HO-1 pathway by increasing the expressions of COX-2, Nrf2, and HO-1 proteins. NaB inhibited the phosphorylation of NF-kappa B and activation of NLRP3 inflammasomes, and reduced the secretion of corresponding inflammatory factors. Furthermore, NaB promoted the ...
Interestingly, MCC950 improved LPS-induced acute lung injury in WT and RBM3 KO mice but inhibited the expression of NLRP3, caspase-1, and IL-1 beta. In conclusion, RBM3 was overexpressed in sepsis patients and LPS-induced mice. RBM3 gene deficiency aggravated sepsis-associated ALI through ...
CBX could attenuate intracellular lipid accumulation and inflammation aggravation in liver and skeletal muscle. Besides, treatment with CBX could significantly reduce expressions of p-I kappa B-alpha, p-NF-kappa B, p-IRS-1, NLRP3 and inflammatory factors, increase expressions of p-PI3K and p-...
Protein levels of cyclin D1, cleaved caspase-3, MYD88, NLRP3, P65, and I[kappa]B[alpha] were determined using western blot assay. After being predicted using Circineractome and starBase, the interaction between miR-944 and circ_0003907 or MYD88 was confirmed using dual-luciferase reporter ...