Constitutive NF-κB activation in AML: Causes and treatment strategies. Crit Rev Oncol/Hematol 2016;98:35-44.Bosman, M.C.; Schuringa, J.J.; Vellenga, E. Constitutive NF-κB activation in AML: Causes and treatment strategies. Crit. Rev. Oncol. Hematol. 2016, 98, 35-44. [CrossRef] [...
Acute myeloid leukaemia (AML) is a heterogeneous disease covering a range of morphological lineages and differentiation stages, but also has number of recurrent chromosomal abnormalities and mutations associated with prognosis. Because of the defined molecular and cytogenetic features, AML has been a focu...
Cancer often develops through the disruption of proper responses to extracellular signals. Thus, understanding how normal cells sense and generate proper respon...
Almost 30% of all acute myeloid leukemias (AML) are associated with an internal tandem duplication (ITD) in the juxtamembrane domain of FMS-like tyrosine kinase 3 receptor (FLT3). Patients with FLT3-ITD mutations tend to have a poor prognosis. MicroRNAs (miRNAs) have a pivotal role in ...
The Toll-like receptor 4 (TLR4) signaling pathway is involved in many aspects of biological functions of AML cells, including the regulation of pro-inflammatory cytokine products, myeloid differentiation, and survival of AML cells. Thus, targeting TLR4 of AML patients for therapeutic purposes should...
We now report that C/EBPalpha or C/EBPalpha leucine zipper AML mutants bind in vivo to the nfkb1 (p50) promoter and induce its expression even in the presence of cycloheximide. Induction of p50 by C/EBPalpha depends on 2 conserved kappaB sites in the nfkb1 p...
After AML induction in Sprague Dawley rats, the same drugs were given to rat groups. Changes in organ weight, haematological profile, and hepatic enzymes were determined. Real-time PCR was used to elucidate the effect on the expression of STMN1, GAPDH, P53 and various TRAIL and NF-kappaB ...
TRAILAMLApoptosisNF-κBTumor necrosis factor-related apoptosis-inducing ldoi:10.1007/s12013-014-0197-9YangZhejiangTianxinZhejiangSunZhejiangXiaodongZhejiangJinZhejiangTaoZhejiangLiuZhejiangXing'eZhejiangMouZhejiangXiaozhouZhejiangCell biochemistry and biophysics...
Results 4-HPR suppressed tumor necrosis factor-alpha- and daunorubin-induced NF-kappa B activation in AML cell lines. The expression of anti-apoptotic gene,BCL2,was downregulated, while expressions of pro-apoptotic genes,cIAP,XIAP, andBID,were increased after 4-HPR treatment. Immunoblots showed...