事实上,通过在过表达p50的细胞中过表达p65来重建两者之间的“正常”化学计量关系,虽然部分取消了p50的肿瘤抑制作用,并导致PD-L1的表达重新开始。部分效应可能是由于即使在p65过表达的条件下,仍有足够数量的p50二聚体来发挥抑制作用。一个有趣且明显的问题与NF-ĸB的两个主要亚基p50和p65之间的定量关系有关,与肿...
事实上,通过在过表达p50的细胞中过表达p65来重建两者之间的“正常”化学计量关系,虽然部分取消了p50的肿瘤抑制作用,并导致PD-L1的表达重新开始。部分效应可能是由于即使在p65过表达的条件下,仍有足够数量的p50二聚体来发挥抑制作用。...
for RELB. The major stimulated form of NF-ĸB is its heterodimerization with the p65 subunit and also, association with the p50 or p52 subunit. Notably, the ubiquitous expression of p50 and p65 is observed in different cell types, while RELB expression is limited to a number of specific ...
图4(A-I)软骨细胞靶蛋白的表达。(A)电泳图片;各蛋白表达量(B) Col10;(C) NF-κB-p65;(D) Mmp13;(E) phospho-NF -κB-p65;(F) phosphor-IKKα/β;(G) PARP;(H) phosphor-c-Jun;(I)cleaved-PARP (J) TNF相关...
Toll Like Receptor 4 (TLR4) and p65 Nuclear Factor Kappa B ( NF - ĸ B ) Expression in Monocyte Cell of Children with Steroid Resistant Nephrotic Syndrome 喜欢 0 阅读量: 46 作者:Tikto,Wahyono,Krisni,Subandiyah,Loeki,Enggar,Fitri,Agustina,Tri,Endharti ...
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We identify the ubiquitin-like (Ubl) domain 2 of USP7 as critical for the interaction and deubiquitination of p65 but dispensable for the interaction of USP7 with the USP7 substrates p53, DAXX, and EBNA1. The Ubl2 domain of USP7 is also required for interaction with the c-Rel subunit ...
7a, ITPR3 knockdown blocked the translocation of NF-κB (P65) from the cytoplasm to the nucleus induced by TNFα in 5637 and 253 J cells. Similar results were also observed in the western blot assay (Fig. 7c). Meanwhile, GSEA analysis was conducted and indicated that 41/50 gene sets...
This is the first study, to the best of our knowledge, to reveal ABLIM1 as a novel E3 ligase targeting IĸBα and its aberrantly high expression promotes CRC growth and metastasis in vitro and in vivo through activating NF-ĸB p65/CCL20 signaling. Notably, the E3 ligase activity of...
A significant (p < 0.05) augmentation in the level of p-AKT, mTOR, and NFκB (p65) was noticed in the T4treated rats in the absence of antioxidant supplementation. Administration of VIT-E and/or CRM showed differential result with respect to their effect on level of p-AKT and their...