NF-κB信号通路参与炎性细胞的调节,有助于炎性疾病的发生和发展,见图2,因此,更好地了解NF-κB的活化和促炎作用的分子机制对炎症性疾病新的治疗策略的发展具有重要意义。 <图1NF-κB target genes involved in inflammation development a...
2012. The NF-kB target genes ICAM-1 and VCAM-1 are differ- entially regulated during spontaneous differentiation of Caco-2 cells. FEBS J 279: 2966-2986.Astarci E, Sade A, Cimen I, Savas B and Banerjee S: The NF‑κB target genes ICAM‑1 and VCAM‑1 are ...
(7 1 ;13)13 Vijay R B Patrick A Current Biology 1997,7(1) ;R9414刘晓核转录因子NF- k B与肿瘤实用肿瘤学杂志2007年第21卷第2期总第88 期191-19615 WL,Moore EE, M co re FA,et a1 Interleykn 一6 delays neulriophilJ Arch Surg ,1996,131:2416 Pahl HL Activators and target genes of ...
Herein, we show that fatigue in HNC patients is associated with elevated activity of the pro-inflammatory transcription factor, NF-kB, and decreased activity of the antiviral IRF transcription factor family. These effects are attenuated in HPV-related HNC, and such patients also show lower levels ...
Although NF-κB target genes have been most intensely studied for their involvement in immunity and inflammation, this transcription factor also regulates cell proliferation, apoptosis and cell migration. Therefore, it is not surprising that NF-κB has been shown to be constitutively activated in sever...
IL1-induced NFκB activation. As component of a DNA-binding complex, NKAP also functions as a transcriptional repressor that acts on NOTCH target genes. Loss of NKAP blocks the development of αβT- cells, suggesting that it is required for their maturation through repression of NOTCH genes....
whose target genes include caspase inhibitors1,6,7,8,9,10. JNK activates the transcription factor c-Jun/AP-1, as well as other targets11,12,13,14,15,16. However, the role of JNK activation in apoptosis induced by TNF-α is less clear17,18. It is unknown whether any crosstalk occurs...
1.Pires B.R.B.,et al.NF-kappaB:Two Side of the Same Coin.Genes (Basel).(2018)Jan 9;9(1).pii:E24.doi:10.3390/genes9010024. 2.Freitas R.H.C.N.,Frage C.A.M.NF-kB-IKKβ pathway as a target for drug development:realities,challenges and perspectives.Curr Drug Targets.(2018)Feb ...
LPS induces NF-κB-dependent genes in tumor cells To examine how NF-κB activation mediates LPS-induced tumor growth, we analyzed expression of NF-κB target genes known to be involved in cell proliferation and apoptosis Karin et al. 2002, Karin and Lin 2002. Tumors were established as above...
Suppressing the expression of NF-κB target genes by an inhibitor of ribosomal protein S3 (RPS3), and anti-inflammatory uses thereof. 来自 mendeley.com 喜欢 0 阅读量: 17 作者:M Lenardo,F Wan 年份: 2008 收藏 引用 批量引用 报错 分享 ...