NFkappaB 是一个大家族,包括: RelAp65 cRel RelB NFkappaB1 p50p105 NFkappaB2 p52p100。其中以 RelAp65 研究最为深入。通常所说的是左边的经典途径,大致意思是这样:非激活状态
The transcription factor nuclear factor kappa B (NF-B) is constitutively active in both cancer cells and stromal cells of breast cancer; however, the preci... HL Chua,P Bhat-Nakshatri,SE Clare,... - 《Oncogene》 被引量: 986发表: 0年 Curcumin (Diferuloylmethane) Inhibits Constitutive and...
Molecular and biochemical analysis indicates that nuclear transcription factor kappaB (NF-kappaB)-inducing kinase (NIK) mediates IKK activation and NF-kappaB transcriptional activity. However, gene deletion studies suggest that NIK triggers gene expression without affecting IkappaBalpha degradation and NF-...
Activation of NF-kappa B by ER stress requires both Ca2+ and reactive oxygen intermediates as messengers. Pahl HL, Baeuerle PA: Activation of NF-kappa B by ER stress requires both Ca2+ and reactive oxygen intermediates as messengers. FEBS Lett 1996, 392:... HL Pahl,PA Baeuerle - 《...
The interplay between proteins of the NF-kappa B/and I kappa B families is a tightly regulated process that ensures appropriate responses to specific envir... Liou, HC,Baltimore, D - 《Current Opinion in Cell Biology》 被引量: 1112发表: 1993年 Stimulation-dependent I kappa B alpha phosphoryl...
Aggarwal, Guggulsterone inhibits NF-kappaB and Ikappa- Balpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis,... S Shishodia,BB Aggarwal - 《Journal of Biological Chemistry》 被引量: 528发表: 2004年 ...
In cells that do not express immunoglobulin kappa light chain genes, the kappa enhancer binding protein NF-kappa B is found in cytosolic fractions and exhibits DNA binding activity only in the presence of a dissociating agent such as sod... PA Baeuerle,DI Baltimore - 《Science》 被引量: 22...
DK Giri,BB Aggarwal - 《Journal of Biological Chemistry》 被引量: 553发表: 1998年 Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 ... The nuclear factor kappa B (NF-kappaB) is believ...
上海玉博生物科技有限公司 主要致力于“NF-kappa-B Non-Canonical Pathway Antibody Sampler Kit CST 4888”的生产销售。多年的“NF-kappa-B Non-Canonical Pathway Antibody Sampler Kit CST 4888”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我公司经营的
Signal-mediated phosphorylation of I kappa B alpha is mediated by a multiprotein complex, the I kappa B kinase (IKK) complex, which is composed of at least three identified subunits. Two of these polypeptides, IKK alpha and IKK beta, also known as IKK1 and IKK2, are the catalytic ...