While p53 activity is associated with apoptosis induction, the stimulation of NF-κB has been demonstrated to promote resistance to programmed cell death. Although the transcription factor NF-κB family is considered as the master regulator of cancer development and maintenance, it has been mainly ...
(RA) treatment. We evaluated important pathways involving nuclear factor kappa B (NF-kappa B), nuclear E2-related factor 2 (Nrf2), glycolytic, and p53 during neuronal differentiation. We also investigated the involvement of reactive oxygen species (ROS) in modulating the gene expression profile ...
Selective killing of lung cancer cells by miRNA-506 molecule through inhibiting NF-kappa B p65 to evoke reactive oxygen species generation and p53 activation 喜欢 0 阅读量: 6 摘要: The tumor suppressor p53, nuclear factor-kappa B ( 关键词:...
While p53 activity is associated with apoptosis induction, the stimulation of NF-κB has been demonstrated to promote resistance to programmed cell death. Although the transcription factor NF-κB family is considered as the master regulator of cancer development and maintenance, it has been mainly ...
Nuclear factor kappa Bp53PrognosisObjectives: To examine the prognostic significance of Gelsolin, NF-kappa B, and p53 in clear cell renal cell carcinoma (CRCC), which has an unpredictable behavior and tendency for recurrence and metastasis. Materials and methods: Immunohistochemistry was performed on ...
Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways. Guo C,Gasparian A V,Zhuang Z,Bosykh D A,Komar A A,Gudkov A V,Gurova K V. Oncegene . 2009Guo C, Gasparian AV, Zhuang Z, Bosykh DA, Komar AA, Gudkov AV, and Gurova KV (2009). 9-...
C., Huygen, S., Gielen, J., Bours, V., Merville, M. P. (2000) Additive effect between NF-kappaB subunits and p53 protein for transcriptional activation of human p53 promoter. Oncogene 19: pp. 4787-4794Benoit V,Hellin AC,Huygenc S. Additive effect between NF-kappa B subunits and ...
NF-kappa BCloning, MolecularSignal TransductionProtein BindingMutationApoptosisThe tumour suppressor p53 inhibits cell growth through activation of cell-cycle arrest and apoptosis, and most cancers have either mutation within the p53 gene or defe...
NF-kappa Bp53S-phasehydroxyureaTNF-alphaapoptosisNuclear factor-kappaB (NF-kappaB) and p53 critically determine cancer development and progression. Defining the cross talk between these transcription factors can expand our knowledge on molecular mechanisms of tumorigenesis. Here, we show that induction ...
Presents research which showed that oncogenic Ras initiates a p53-independent apoptotic response that is suppressed through the activation of nuclear factor kappa B (NF-kappa-B). Mutation and function of Ras proto-oncogene in humans; Ras-responsive transcription factors in transformation; Implications ...