The growing prevalence and incidence of heart failure (HF) with preserved ejection fraction (HFpEF) is an important problem in a society with an aging population, because the condition is seen predominantly in the elderly. As treatments for hypertension and coronary artery disease have advanced and...
Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing muscle biology-directed drug candidates as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology ...
“For HFmrEF and HFpEF, we recommend diuretics, SGLT2 inhibitors, and angiotensin receptor-neprilysin inhibitors (ARNIs) as major treatments,” the professor said.
The medical community has long recognized the strong relationship between CVD and diabetes. Compounding concerns over this association have been questions about the CV safety of diabetes treatments, in particular the effect of these medications on the risk for CV...
Larger long-term studies are needed to assess the efficacy and safety of MK-0616 in the context of available treatments NOAH-AFNET 650NCT02618577 Investigator-initiated, DB, DD, R trial2536 patients (mean age 78 years) with AHREs lasting for at least 6 min and at least one additional ...
since most of the rationale for AVP antagonism in HFrests onthe success of other neurohormonally-based treatments in HFrEF, it would probably make sense to focus on HFrEF patients sinceHFpEFis a heterogeneous syndrome in which the role of neurohormonal imbalance indisease progressionis almost compl...
The company spokesperson said it has filed for HFpEF as a new indication. Lilly is expecting results from its trial of tirzepatide for HRpEF in obese patients later this year. A Coverage Loophole? Medicare is prohibited by law from covering weight-loss treatments, so classifying Wegovy ...
Moving forward, Clements said she believes anti-obesity medications will continue to become more effective, even reaching the point of efficacy similar to bariatric surgery. Pharmacists can continue playing a large role in these treatments through educating providers, counseling pa...
(NASH; metabolic dysfunction-associated steatohepatitis, MASH) and cancer and possible treatments for these complications were also explored. It is generally assumed that treatment of chronic diseases is equally effective for all patients. However, as discussed at the Summit, this assumption may not ...
Most important, is there a science to recovery that creates insight regarding new mechanisms and treatments of left ventricular (LV) dysfunction? In this issue of JAMA Cardiology, Kalogeropoulos et al2 add nicely to this emerging phenotype with a careful single-center analysis of all patients ...