Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA Lea K. Davis Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA Stephan Ripke Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard...
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Nat. Commun. 9, 3221 (2018). Article PubMed PubMed Central CAS Google Scholar Ji, X. et al. Protein-altering germline mutations implicate novel genes related to lung cancer development....
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Together, these pathways may be crucial for the emergence of a tumorigenic environment-adaptive, unique response that is represented in the alteration of the allelic frequencies of mtDNA mutations. The nuclear insertions of mitochondrial origin (NumtS), which have been linked to cancer, should be ...
Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ...
Another novel therapeutic approach is targeting the microenvironment of hematopoietic tumors [16,17]. The role of the bone marrow microenvironment (BMM) in driving disease progression is widely recognized, with chemokine receptors (CXCR4), adhesion molecules, signal transduction pathways and hypoxia-relat...
I believe even more now than before that there’s only one reason I venture down the pathways of life…and that is to find New Journeys on Old Roads. Welcome back! I’ll begin posting stories, photos, trip routes and ramblings over the next few weeks. Follow along…let’s travel acros...
Keohane, M.S., Department of Health Policy, Vanderbilt University School of Medicine, 1500 21st Avenue South, Nashville, TN 37212; e-mail: laura.keohane@vanderbilt.edu. Publication History Article first published online: 6 AUG 2015 Funded by National Institute on Aging. Grant Number: P01 AG-...
Baldock PA, Sainsbury A, Allison S, Lin EJ, Couzens M, Boey D, Enriquez R, During M, Herzog H, Gardiner EM (2005) Hypothalamic control of bone formation: distinct actions of leptin and Y2 receptor pathways. J Bone Miner Res 20:1851–1857 CrossRef Baldock PA, Allison S, McDonald MM...
Molecular pathways: Cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treat‑ ment. Clin Cancer Res. 2015;21:1789–94. Available from: https://doi.org/ 10.1158/1078-0432.ccr-13-2490. 35. Liu X, Teng Y, Wu X, Li Z, Bao ...