L. The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol. Cell 39, 8–24 (2010). Article CAS PubMed PubMed Central Google Scholar Luo, X. & Kraus, W. L. On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. ...
The molecular mechanism of inactivation, elucidated in a cell-free system by Endo and colleagues (2), is the removal of a specific adenine of the 28 S rRNA. This damage, which has been shown to occur in RIP-treated cells, has been generally accepted as responsible for cytotoxicity (1). ...
The investigation of symmetric/asymmetric structures and their applications in mathematics (in particular in operator theory and functional analysis) is useful and fruitful. A metric space has the property of symmetry. By looking in the same direction an
For the cancer genomics era, there is a need for clinically annotated close-to-patient cell lines suitable to investigate altered pathways and serve as high-throughput drug-screening platforms. This is particularly important for drug-resistant tumors lik
Messenger RNA (mRNA) is a pivotal molecule of life, involved in almost all aspects of cell biology. As the subject of basic and applied research for more than 5 decades, mRNA has only recently come into the focus as a potentially powerful drug class able to deliver genetic information. Synt...
(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) copolymers from less than 1 to 13% [81] and generate P34HB with 1.4 to 18.4 mol% of 4HB [82].Similarly, the molecular weight of HA was increased by decreasing the expression of FtsZ (initiating cell division) and changing the distribution ...
[191,192,193]. Targeting and regulating these overexpressed receptors can facilitate the direct delivery of cytotoxic drugs, antigens or adjuvants to cancer cells. After drug-induced cell death, dying tumor cells express calreticulin on their surface and release endogenous damage-associated molecular ...
Cell nuclei were counterstained with Mayer's hematoxylin. Arrows: 1, tumorous cells; 2, membrane pores; 3, leukocytes. Molecular Analysis We studied Hep3B cells, which carry a p53 deletion previously described by Southern blot,12 and HepG2 cells, the p53 gene of which is nonrearranged. In...
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