However, the molecular and cellular regulatory mechanisms underlying the formation and role of NET in cancer remain unclear. This review just summarizes the recent progress in regulatory mechanisms about the formation of NETs and their role in cancers.Zhang, Zhiyuan...
neutrophil extracellular trap formation通路解释 中性粒细胞外围陷阱形成(neutrophil extracellular trap formation,NETosis)是一种特殊的中性粒细胞死亡方式,用于对抗细菌和其他病原体的感染。 NETosis过程包括以下几个步骤: 1.活化:中性粒细胞受到感染或其他刺激后,会经历一系列内部信号转导事件的激活,包括细胞膜上的...
neutrophilextracellulartrapformationisindependentofdenovogene 系统标签: neutrophilextracellularnovoformationtrap粒细胞 RESEARCHARTICLENeutrophilExtracellularTrapFormationIsIndependentofDeNovoGeneExpressionGabrielSollberger*☯,BorkoAmulic*☯,ArturoZychlinskyDepartmentofCellularMicrobiology,MaxPlanckInstituteforInfectionBiology,...
neutrophilextracellulartrapformationisindependentofdenovogene 系统标签: neutrophilextracellularnovoformationtrap粒细胞 RESEARCHARTICLE NeutrophilExtracellularTrapFormationIs IndependentofDeNovoGeneExpression GabrielSollberger* ☯ ,BorkoAmulic* ☯ ,ArturoZychlinsky DepartmentofCellularMicrobiology,MaxPlanckInstituteforInfec...
Signal inhibitory receptor on leukocytes-1 limits the formation of neutrophil extracellular traps, but preserves intracellular bacterial killing. J. Immunol. 196, 3686–3694 (2016). CAS PubMed Google Scholar Hirschfeld, J. et al. Neutrophil extracellular trap formation in supragingival biofilms. Int...
Further studies in PAD4−/− mice confirmed a significant role for neutrophil extracellular trap formation in the adjuvant activity of Alum. By revealing neutrophils recruited to the site of Alum injection as a source of the DNA that is detected by the immune system this study provides the ...
Furthermore, stimulation of neutrophils with bacteria common to mammary gland infections leads to neutrophil extracellular traps being formed in milk. Some bacteria tested stimulated enhanced formation of neutrophil extracellular traps in milk compared to culture media. Therefore, being unaffected by ...
New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation for, to our ... HD Lewis,J Liddle,JE Coote,... - 《Nature Chemical ...
et al. P-selectin promotes neutrophil extracellular trap formation in mice. Blood 126, 242–246 (2015). 34. Hakkim, A. et al. Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. Nat Chem Biol 7, 75–77 (2011). 35. Gangat, N. et al. DIP...
Since we had observed that neutrophils and other granulocytes release mitochondrial DNA (mtDNA) in the formation of extracellular DNA traps3, we hypothesized that mitochondrial dynamics might be important for mtDNA release. Five members of the GTPase dynamin family, namely mitofusin-1 (MFN1), mitofusi...