富集到的通路主要涉及神经活性配体-受体相互作用(neuroactive ligand-receptorinteraction)、环腺苷酸信号通路(cAMPsignaling pathway)、磷脂酰肌醇3-激酶-蛋白激酶通路(PI3K-Akt signaling pathway)等,表明34个核心靶点可能是主要通过调节这些通路来起到治疗或干预疾病的作用。 2.7.4成分-靶点-通路网络构建 根据筛选得到的Z...
KEGG通路富集分析结果如图3所示,共有靶点的涉及的通路共28条,提示养血清脑丸通过多通路而发挥偏头痛的治疗作用。根据P值大小,排名前5的通路包括神经活性配体受体相互作用(neuroactive ligand-receptor interaction)、5-羟色胺能突触(serotonergic synapse)、钙信号通路(calcium signaling pathway)、cAMP信号通路(cAMP signal...
And then, the neuroactive ligand-receptor interaction pathway was over-activated in high-HRD tumors and associated with immunosuppression in colon cancer with high HRD. Besides, the pathway was associated with prognosis and immunotherapy response in COAD. Moreover, genes in this pathway such as LTB4...
KEGG PATHWAY_ Neuroactive ligand-receptor interaction - Rattus norvegicus (rat)-TRPV1 [ Pathway menu
1.2 Molecular interactions 分子相互作用 当我们考虑药物和蛋白质的相互作用的时候,我们其实在考虑分子层面的相互作用 下面是视频的翻译,看视频会好理解一些。 比方说,hydrogen bonds让分子紧紧的连接到蛋白质上,疏水性配体原子中的疏水性蛋白质原子群也是如此.疏水封闭的氢键也加强了末端与蛋白质的结合.其他吸引配体到...
Adkins DE, Khachane AN, McClay JL, Aberg K, Bukszar J, Sullivan PF, van den Oord EJ (2012) SNP-based analysis of neuroactive ligand-receptor interaction pathways implicates PGE2 as a novel mediator of antipsychotic treatment response: data from the CATIE study. Schizophr Res 135:200-201....
Adkins DE, Khachane AN, McClay JL, et al. SNP-based analysis of neuroactive ligand-receptor interaction pathways implicates PGE2 as a novel mediator of antipsychotic treat- ment response: data from the CATIE study. Schizophr Res. 2012;135:200-201....
Genes in neuroactive ligand-receptor interaction pathways.Chuanwang CaoZhiying WangChangying NiuNicolas DesneuxXiwu Gao
Validation analysis for targets in neuroactive ligand-receptor interaction pathway.Yan, KongXijun, LiangLin, LiuDongdong, ZhangChao, WanZhenji, GanLiudi, Yuan
The neuroactive steroid 3 α -hydroxy-5 β -pregnan-20-one is a two-component modulator of ligand binding to the GABA A receptor. Eur J Pharmacol. 1994; 269 :157–163.Hawkinson JE, Kimbrough CL, McCauley LD, Bolger MB, Lan NC, Gee KW (1994b) The neuroactive steroid 3α-hydroxy-5...