Nature子刊|新发现颅内恶性肿瘤更有效免疫治疗的靶点(GR)-CCR8 2024年7月24日,苏州大学的时玉舫和邵常顺团队在《Cellular & Molecular Immunology》上发表了一篇题为“Targeting the glucocorticoid receptor-CCR8 axis mediated bone marrow T cell sequestration enhances infiltration of anti-tumor T cells in intracr...
2023年4月,加拿大多伦多大学Sowmya Viswanathan的研究团队在Nature子刊Cellular & Molecular Immunology杂志上发表题为“Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success”的研究长文[1],该团队评估了15项随机对照临床试验(RCTs)和11项使用培养扩...
1. Holehouse, A. S. & Kragelund, B. B. The molecular basis for cellular function of intrinsically disordered protein regions. Nat. Rev. Mol. Cell Biol. (2023). 2. Akdel, M. et al. A structural biology community assessment of AlphaF...
CAR-T细胞的新靶点:uPAR 细胞衰老(Cellular senescence)是机体生理或病理过程中常见的现象,其特征是细胞表现出稳定性的细胞周期停滞以及分泌系列分子调节组织微环境。正常生理过程中,细胞衰老可阻止癌前细胞的扩增从而抑制肿瘤的发生,并且在伤口愈合过程中也具有有益作用。 病理状况下,衰老细胞的异常聚集则会产生炎症性微...
近期,香港大学吕力为教授的团队在《cellular & molecular immunology》上发表题为“Epigenetic regulation of B cells and its role in autoimmune pathogenesis” 的综述,在这篇综述中,主要介绍了表观遗传机制的最新概况,重点是它们在调控功能性B细胞亚群中的作用。此外,还讨论了B细胞中的表观遗传失调,并强调其对自身...
Cellular immunity is a protective immune process that involves the activation of phagocytes, antigen-sensitized cytotoxic T cells and the release of cytokines and chemokines in response to antigen. Cellular immunity is most effective against cells infected with viruses, intracellular bacteria, fungi and...
[14] d'Adda di Fagagna, F. Living on a break: cellular senescence as a DNA-damage response. Nat Rev Cancer 8, 512–522 (2008). https://doi.org/10.1038/nrc2440 [15] Stolk, L., Perry, J. R., Chasman, D. I., He, C., Mangino, M., Sulem, P., Barbalic, M., Broer,...
4. Korolchuk, V. I. et al. Lysosomal positioning coordinates cellular nutrient responses.Nat. Cell Biol.13, 453–460 (2011). 5. Jia, R. & Bonifacino, J. S. Lysosome positioning influences mTORC2 and AKT signaling.Mol. Cell75, 26...
证明了联合分析的必要性,同时展示利用单细胞技术快速生成泛转录组,以深入了解植物细胞类型进化,并提供新方法来探索重要作物物种遗传模块和细胞特征之间的联系。参考文献A pan-grass transcriptome reveals patterns of cellular divergence in crops. Nature ,2023 ...
secretory cells and slow cycling LGR5+cells have been shown to contribute to regeneration whereas the tranional regulator YAP1, which is important for intestinal regeneration, was suggested to induce a pro-survival phenotype in LGR5+cells. Thus, whether cellular plasticity or distinct cell population...