The degree of steatosis (none/mild vs. moderate/severe) correlated significantly with postoperative morbidity (P = 0路03) and in-patient stay but not post-operative mortality. There was no significantly increased surgical risk conferred with the presence of steatohepatitis, although one patient had ...
固有免疫的激活进一步促进肝脏炎症细胞的浸润和累积,从而加剧肝脏的炎症和损伤,而肝星状细胞(hepatic stellate cells,HSCs)的激活是最终导致肝纤维化的基础[9]。鉴于固有免疫在NAFLD发病机制中的核心作用,现重点讨论巨噬细胞在NAFLD和NAS...
本文从NASH药物临床开发评价视角,结合药物实例阐述目前开发过程中的现状,困难挑战等。 非酒精性脂肪性肝病(Nonalcoholic Fatty Liver Disease,NAFLD)是一种与胰岛素抵抗和遗传易感密切相关的代谢应激性肝脏损伤。疾病谱包括非酒精性肝脂肪变(Nonalcoholic ...
NAFLD is a spectrum of chronic liver diseases varying from isolated excessive hepatic triglyceride accumulation and steatosis (nonalcoholic fatty liver, NAFL), to a more serious process with inflammation and hepatocyte damage (steatohepatitis) [1]. Patients with only NAFL carry a very low risk of a...
背景技术:::NAFLD和NASH非酒精性脂肪肝病(NAFLD)是在美国影响多达3-5个成年人中1个和10个儿童中1个的疾病,并是指少量喝酒或不喝酒的人的肝脏中积聚过多脂肪的病症。NAFLD的最常见形式是称为肝脂质沉着症(hepaticsteatosis)(脂肪肝)的不严重病症,其中脂肪积聚在肝细胞中:虽然这不正常,但是其自身可能不会损坏...
Genetic inactivation of the LIGHT (TNFSF14) cytokine in mice restores glucose homeostasis and diminishes hepatic steatosis The effect of Light deficiency was also evaluated in hepatic tissue and in inflammation in HFHCD-fed Irs2+/- mice with impaired insulin signalling. ... A Herrero-Cervera,N ...
The Liver in Type 2 Diabetes Mellitus Liver biopsy series of individuals with type 2 diabetes and hepatic steatosis demonstrate that liver damage has progressed to NASH in most and that a ... AM Diehl,SS Choi - 《Contemporary Endocrinology》 被引量: 2发表: 2008年 加载更多来源...
定义 非酒精性脂肪性肝病（NonalcoholicFattyLiverDisease，NAFLD）是一种与胰岛素抵抗和遗传易感密切相关的代谢应激性肝脏损伤，疾病谱包括非酒精性肝脂肪变（NonalcoholicHepaticSteatosis）（等同非酒精性脂肪肝NAFL〔Nonalcoholicfattyliver〕）、非酒精性脂肪性肝炎（NonalcoholicSteatohepatitis，NASH）及NASH相关肝硬化和肝...
45.Bykov I,Jauhiainen M,Olkkonen VM et al.Hepatic gene expression and lipid parameters in complement C3(-/-)mice that do not develop ethanol-induced steatosis.J Hepatol 2007;46(5):907-914.PM:17321001 [0178] 46.Bykov I,Junnikkala S,Pekna M,Lindros KO,Meri S.Complement C3 contributes...
NAFLD是一种与胰岛素抵抗(insulin resistance,IR)和遗传易感密切相关的代谢应激性肝损伤,疾病谱包括非酒精性肝脂肪变(non-alcoholic hepatic steatosis)、非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)、肝硬化和肝细胞癌(hepatocellular carcinoma,HCC)。NAFLD不仅可以导致肝病残疾和死亡,还与代谢综合征(...