首先是NASH的易名,从非酒精性脂肪性肝炎(Nonalcoholic Steatohepatitis)更改为代谢功能障碍相关脂肪性肝炎(MASH,Metabolic dysfunction-associated steatohepatitis)。其实这个更名在去年夏天就已经发生了,这是根据德尔菲共识命名法(Delphi Consensus Nomenclature)做出的,目的是呼吁人们认识到精确疗法和以患者为中心的护理在治疗MAS...
NASH(non-alcoholic steatohepatitis),即非酒精性脂肪性肝炎,是由肝脏中脂肪堆积引起的肝脏疾病和炎症。根据流行病学数据,全球酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)发病率约25%,这些患者约有10-20%的可能进展为NASH,全球各地NASH发病率约为1.5%至6.5%,中国约为3.5%(即目前美国NASH患者人数约为1...
国际NASH日是一个旨在提高公众对非酒精性脂肪性肝病(Non-Alcoholic Steatohepatitis,NASH)的认识和意识的全球倡议。2018年的6月12日被定为首个国际NASH日,为人们提供了一个平台,以增加对这种常见的肝脏疾病的认识,并促进研究、教育和支持相关的倡议。 什么是 NAFLD/NASH? NASH是一种与肥胖、2型糖尿病和代谢综合征...
非酒精性脂肪性肝炎(nonalcoholic steatohepatitis,NASH)也称代谢性脂肪性肝炎,主要表现为不明原因的肝内脂肪蓄积,通常伴有炎症和细胞内损伤。在过去20年里,其前驱疾病-非酒精性脂肪性肝病(NAFLD)的发病率已翻倍,成为导致发达国家和地区的人们患慢性肝病及肝酶异常的首要原因。在美国, NASH已成为继慢性丙型肝炎之后美国...
1. Madrigal Pharmaceuticals Announces FDA Approval of Rezdiffra™ (resmetirom) for the Treatment of Patients with Noncirrhotic Nonalcoholic Steatohepatitis (NASH) with Moderate to Advanced Liver Fibrosis. Retrieved March 14, 2024 from https ://ir.madrigalpharma.com/news-releases/news-release-...
非酒精性脂肪性肝病(NAFLD,Nonalcoholic fatty liver disease)是一种与胰岛素抵抗及遗传易感密切相关的进行性肝损伤疾病,其疾病理过程由轻及重依次包含非酒精性肝脂肪变、非酒精性脂肪性肝炎(NASH)及NASH相关肝硬化和肝细胞癌。目前NASH的小鼠模型主要包括饮食诱导和基因敲除+饮食诱导。 NAFLD演化过程 一 正常小鼠饮食...
Nonalcoholic fatty liver disease (NAFLD) represents a histological spectrum ranging from benign hepatic steatosis (NAFL) to nonalcoholic steatohepatitis (NASH). NAFLD is closely associated with insulin resistance (IR), and although the role of IR in NAFLD has been an area of intense investigation,...
6. Hannah , W.N., Jr. & Har rison, S.A. Noninvasive imaging methods to determine severity of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis . Hepatology 64, 2234-2243 (2016). 7. Wong , V.W., Adam s, L.A., de Ledinghen , V., Wong , G.L. & Sookoian, S...
【2】 Satapathy SK, Bernstein DE, Roth NC. Liver transplantation in patients with non-alcoholic steatohepatitis and alcohol-related liver disease: the dust is yet to settle. Transl Gastroenterol Hepatol. 2022 Jul 25;7:23. doi: 10.21037/tgh-2020-15. PMID: 35892055; PMCID: PMC9257537.来源：...
【2】 Satapathy SK, Bernstein DE, Roth NC. Liver transplantation in patients with non-alcoholic steatohepatitis and alcohol-related liver disease: the dust is yet to settle. Transl Gastroenterol Hepatol. 2022 Jul 25;7:23. doi: 10.21037/tgh-2020-15...