Targeting active moieties to a specific site is achieved by appropriate nanotechnology as targeted drug delivery system has various drawbacks. In order to combat this problem various dosage forms have been developed with nanotechnology among those the one with discrete functionalized pa...
Glutathione-responsive nanospongesHepG2 cellsHepatotoxicityRat precision-cut liver slicesβ-CyclodextrinThe potential mammalian hepatotoxicity of a new class of GSH-responsive cyclodextrin-based nanosponges loaded with the anticancer drug doxorubicin (Dox-GSH-NS) was investigated. Previous studies showed that...
The ideal delivery system will solubilize the drug, lead the therapy to the target site, and release the therapy to fulfill the individual need of the patient and disease stage. Nanosponges are one of such effective drug carriers which conquer the problems of drug toxicity and poor bioavailabilit...
Nanosponges: A versatile drug delivery system. Effective targeted drug delivery systems have been a dream for long time. The invention of nanosponges has become a significant step towards overcoming these problems. These small sponges can circulate around the body until they encounte... Naga,Silpa...
In order to suppress inflammatory responses, nanoparticle interaction with biological system has recently been studied for nano- particulate delivery systems29. The results (inset of Fig. 7) show that ZC@CC sponges could more significantly suppress the macrophage inflammatory protein (MIP) production...
To the best of our knowledge, a controlled drug-delivery system consisting of AuNRs and NSs ICs has not been reported to date. Our results show that NSs–AuNRs complexes are efficient and non-toxic materials that might eventually be considered as a potential technology for tumor therapy. 2. ...
In the last few years, a nanosponge has been proposed as an advanced drug delivery system involving the reaction of cyclodextrin with a suitable cross-linking agent for encapsulation of difficult-to-formulate moieties [5–8]. These are hyper cross-linked nanoporous structures reported to form ...
A good targeted drug delivery system should have the following characteristics: a) composed by biocompatible and biodegradable materials, b) fast assembly and cargo loading, c) minimal systemic leaking during delivery, and d) fast release upon arrival at interested site.58 We have designed (choleste...
Since the discovery of RNA interference (RNAi), small interfering RNA (siRNA) has been powerful tools for gene downregulation in biomedical applications. Despite the outstanding efficacy of siRNA, the development of a therapeutic delivery system remains
These findings also support the existence of a specific phase diagram of the cyclodextrin nanosponges hydrogel, where the molecular structure of the cross-linking agent used during the synthesis of nanosponge plays a fundamental role in defining the nano- and microscopic properties of the system. ...