Targeted therapyMonoclonal antibodies and vaccines have widely been studied for the immunotherapy of cancer, while their large size appears to limit their functionality in solid tumors, in large part due to unique properties of tumor microenvironment such as high pressure of tumor interstitial fluid. ...
Chimeric antigen receptor-based T-cell immunotherapy is a promising strategy for treatment of hematological malignant tumors; however, its efficacy towards solid cancer remains challenging. We therefore focused on developing nanobody-based CAR-T cells that treat the solid tumor. CD105 expression is up...
Nanobody-based cancer therapy of solid tumors. Nanomedicine 2015, 10, 161–174. [Google Scholar] [CrossRef] Kolkman, J.A.; Law, D.A. Nanobodies–from llamas to therapeutic proteins. Drug Discov. Today: Technol. 2010, 7, e139–e146. [Google Scholar] [CrossRef] [PubMed] Hu, Y.; ...
Oliveira, S., Heukers, R., Sornkom, J., Kok, R. J., van Bergen En Henegouwen, P. M.Targeting tumors with nanobodies for cancer imaging and therapy.Journal Of Controlled Release.172(3), 607-617 (2013). Kijanka, M.,et al.Rapid optical imaging of human breast tumour xenografts us...
Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of antigenic epitopes capable of evoking the most potent CAR activation is an important objective in optimizing immune therapy. In solid tumors, the B7-H3 transmembrane protein is an emerging target that harbour...
Altogether, we show that engineered HN3 CAR T cell therapy demonstrates strong potential for treatment of aggressive HCCs enabled by Wnt dysregulation.Aarti KolluriMayo Clinic, Bethesda, MD;Dan LiNIH/NCI, Bethesda, MD;Nan LiNatl Cancer Inst, Elkridge, MD;Mitchell Ho...
Cancer is the leading cause of death in the geriatric dog population. Currently, the use of immune checkpoint inhibitors (ICIs) such as anti-CTLA4 antibodies has markedly improved the prognosis of several cancers in their advanced stages. However, ICIs t
Antibody or Antibody Fragments: Implications for Molecular Imaging and Targeted Therapy of Solid Tumors. Front. Immunol. 2017, 8, 1287. [CrossRef] [PubMed] 96. Debie, P.; Lafont, C.; Hansen, I.; Defrise, M.; Van Willigen, D.M.; van Leeuwen, F.; Gijsbers, R.; D'huyvetter, M...