Targeted therapyMonoclonal antibodies and vaccines have widely been studied for the immunotherapy of cancer, while their large size appears to limit their functionality in solid tumors, in large part due to unique properties of tumor microenvironment such as high pressure of tumor interstitial fluid. ...
Cancer is the leading cause of death in the geriatric dog population. Currently, the use of immune checkpoint inhibitors (ICIs) such as anti-CTLA4 antibodies has markedly improved the prognosis of several cancers in their advanced stages. However, ICIs t
Immune checkpoint inhibition is an important strategy in cancer therapy. Blockade of CTLA-4 and PD-1/PD-L1 is well developed in clinical practice. In the last few years, LAG-3 has received much interest as an emerging novel target in immunotherapy. It wa
TNF-α plays an important role in the signal pathway leading to resolution of infection and initiation of tissue repair [1]. In contrast, it will trigger a cytokine storm in cancer CAR-T immunotherapy and antiviral therapy resulting in autoimmune diseases, such as rheumatoid arthritis and Crohn'...
Altogether, we show that engineered HN3 CAR T cell therapy demonstrates strong potential for treatment of aggressive HCCs enabled by Wnt dysregulation.Aarti KolluriMayo Clinic, Bethesda, MD;Dan LiNIH/NCI, Bethesda, MD;Nan LiNatl Cancer Inst, Elkridge, MD;Mitchell Ho...
Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of antigenic epitopes capable of evoking the most potent CAR activation is an important objective in optimizing immune therapy. In solid tumors, the B7-H3 transmembrane protein is an emerging target that harbour...
Antibody or Antibody Fragments: Implications for Molecular Imaging and Targeted Therapy of Solid Tumors. Front. Immunol. 2017, 8, 1287. [CrossRef] [PubMed] 96. Debie, P.; Lafont, C.; Hansen, I.; Defrise, M.; Van Willigen, D.M.; van Leeuwen, F.; Gijsbers, R.; D'huyvetter, M...