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Finally, these results do not exclude the possibility that other types of large assemblies or fibrils do penetrate into the cell cytosol, and would therefore be detected by the sensor. This issue could be tested more thoroughly in the future. It is known that many types of fibril-like assembl...
The synthetic dimeric PscFvLHFc and tetrameric 2× PscFvLHFc ligands were designed to induce dimeric and tetrameric AIP1-3VHHFas receptor assemblies, respectively. Tetramerization of 2× PscFvLHFc was achieved by linker peptide connected tandem arrangement of two PscFv fused to the IgG1-Fc...
Nanobody-based detection of ALFA-tagged proteins in immunofluorescence applications.aSketch of NbALFA bound to the ALFA-tag. Given are ALFA sequences for tagging at various positions.bSequence of NbALFA. Gray boxes indicate CDRs 1–3 (complementarity determining regions 1–3; AbM definition).cCO...