Revets H, De Baetselier P, Muyldermans S. Nanobodies as novel agents for cancer therapy. Expert Opin Biol Ther (2005) 5(1):111-24. doi:10.1517/14712598.5.1.111Revets H, De Baetselier P, Muyldermans S. Nanobodies as novel agents for cancer therapy[J].Expert Opin Biol Ther.2005,...
In cancer therapy, humanization strategies for camelid-derived Nbs could minimize the risk of immune responses [68]. One approach involves grafting the Nb with antigen specificity of interest onto a universal humanized Nb scaffold (h-NbBcII10FGLA) or replacing nonhuman Nb CDRs with human Ab CDRs...
SARS-CoV-2 RBD-specific nanobodies can be categorized as those that target the receptor ACE2-binding sites to completely, or partially, compete with the ACE2 for binding to the RBD (i.e., aRBD-2, aRBD-5, aRBD-7, and NB1B5), or those that target conserved RBD epitopes in cryptic ...
SARS-CoV-2 RBD-specific nanobodies can be categorized as those that target the receptor ACE2-binding sites to completely, or partially, compete with the ACE2 for binding to the RBD (i.e., aRBD-2, aRBD-5, aRBD-7, and NB1B5), or those that target conserved RBD epitopes in cryptic ...
Alirahimi E, Kazemi-Lomedasht F, Shahbazzadeh D et al (2018) Nanobodies as novel therapeutic agents in envenomation. Biochim Biophys Acta Gen Subj 1862:2955–2965 Article CAS PubMed Google Scholar Koenig PA, Das H, Liu H et al (2021) Structure-guided multivalent nanobodies block SARS-CoV...
Mechanistically, CXCR7-targeting Nanobodies did not inhibit cell cycle progression but instead reduced secretion of the angiogenic chemokine CXCL1 from head and neck cancer cells in vitro, thus acting here as inverse agonists, and subsequent angiogenesis in vivo. Hence, with this novel class of ...
The Hynes team targeted the nanobodies to the tumors' extracellular matrix, or ECM -- aiming imaging agents not at the cancer cells themselves, but at the environment that surrounds them. Such markers are common to many tumors, but don't typically appear on normal cells. ...
Nanotechnology is a multidisciplinary field that brings together diverse fields of research and development such as engineering, biology, physics and chemi... PV Baptista - 《Current Cancer Therapy Reviews》 被引量: 37发表: 2009年 Nanobiodevices for Biomolecule Analysis and Imaging Nanobiodevices have...
A wide variety of tumor biopsies was profiled, showing for the first time high expression of CXCR7 in head and neck cancer. Using a patient-derived CXCR7-expressing head and neck cancer xenograft model in nude mice, tumor growth was inhibited by CXCR7-targeting Nanobody therapy. ...
Prostate cancer is one of the most common cancers in men and its incidence has increased dramatically in the last decade. This increase in the detection of this type of cancer is based more on the detection of PSA or PSMA antigens as the most important s