Expert Opinion on Biological TherapyRevets H, Baetselier PD, Muyldermans S. Nanobodies as novel agents for cancer therapy. Expert Opin Biol Ther. 2005;5(1):111–24.Revets H, De Baetselier P, Muyldermans S. Nanobodies as novel agents for cancer therapy. Expert Opin Biol Ther. 2005;...
Their small size, stability, specificity, affinity and ease of manufacture make them appealing for use as imaging agents in the laboratory and the clinic. With the recent surge in immunotherapeutics and the success of cancer immunotherapy, it is important to be able to image immune responses and...
One promising set of antibody fragments with favorable biochemical and physical properties are derived from heavy-chain-only antibodies in camelids and known as nanobodies. This thesis focuses on the therapeutic applications of nanobodies for cancer treatment. Towards this end, two methods were ...
Nanobodies as therapeutics: Big opportunities for small antibodies 2016, Drug Discovery Today Show abstract Emerging new therapeutic antibody derivatives for cancer treatment 2022, Signal Transduction and Targeted Therapy Nanobodies: Next Generation of Cancer Diagnostics and Therapeutics 2020, Frontiers in On...
it is conceivable that blocking the enzymatic activity of CD38 may be of therapeutic benefit in cancer. If so, this could influence the choice of nanobodies as therapy candidates for pre investigational new drug experiments. In particular, use of the antagonistic nanobody family 4 that binds inde...
1). Consistent with previous studies, we found that US28-mediated NFAT activation was dependent on constitutive signaling as NFAT activation was observed for all different US28 constructs except for the US28 R129A G protein uncoupled mutant18. Then, we analyzed the effect of VUN100bv on US28...
Mechanistically, CXCR7-targeting Nanobodies did not inhibit cell cycle progression but instead reduced secretion of the angiogenic chemokine CXCL1 from head and neck cancer cells in vitro, thus acting here as inverse agonists, and subsequent angiogenesis in vivo. Hence, with this novel class of ...
Nanobodies as novel agents for cancer therapy. Expert Opin Biol Ther. 2005;5(1):111–24. https://doi.org/10.1517/14712598.5.1.111. Article CAS PubMed Google Scholar Wesolowski J, Alzogaray V, Reyelt J, Unger M, Juarez K, Urrutia M, et al. Single domain antibodies: promising ...
The Potential of Nanobodies for COVID-19 Diagnostics and Therapeutics Dhaneshree Bestinee Naidoo Anil Amichund Chuturgoon Molecular Diagnosis & Therapy(2023) Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor ...
Development of HER2-targeted nanobodies for molecular optical imaging and therapy of breast cancer. PhD thesis, Utrecht Univ. (2014). 12. Mohan, R. et al. End-binding proteins sensitize microtubules to the action of microtubule-targeting agents. Proc. Natl Acad. Sci. USA 110, 8900–8905 (...