Nanodynamic therapy (NDT) exerts its anti-tumor effect by activating nanosensitizers to generate large amounts of reactive oxygen species (ROS) in tumor cells. NDT enhances tumor-specific targeting and selectivity by leveraging the tumor microenvironment (TME) and mechanisms that boost anti-tumor ...
近日,美国亚利桑那大学的研究团队在《Nature Nanotechnology》上发表题为Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy的研究文章,该项研究发明了一种新型纳米治疗平台以及跨膜转运技术作为“加热”肿瘤的方法,采用抗癌药物喜树...
并且,该VEGF靶向纳米药物能有效地在肿瘤部位积累并抑制小鼠肿瘤的生长。相关研究以“Molecularly Imprinted Nanomedicine for Anti-angiogenic Cancer Therapy via Blocking Vascular Endothelial Growth Factor Signaling” 为题,发表在Nano Letters上。刘...
这些纳米酶在生物医学应用,特别是癌症治疗方面有着明显优势。 Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy Xiaodong Zhang, Xiaokai Chen, Yanli Zhao* Nano-Micro Letters (2022)14: 95 https://doi.org/10.1007/s...
Pyroptosis is a gasdermin-mediated programmed necrosis that occurs via membrane perforation and that can be exploited for biomedical applications in cancer therapy. However, inducing specific pyroptotic cancer cell death while sparing normal cells is challenging. Here, we report an acid-activatable nano...
该研究所提供的结果表明,调节肿瘤组织的硬度可以增强肿瘤中的基因编辑行为,并为利用协同式LNP和其他纳米颗粒系统进行癌症基因编辑治疗提供新的思路。相关工作以“Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy”为题发表在Nature Nanotechnology。
[1] Ling-Hong Xiong, Langyi Yang, Jiangtao Geng, Ben Zhong Tang, and Xuewen He, All-in-One Alkaline Phosphatase-Response Aggregation-Induced Emission Probe for Cancer Discriminative Imaging and CombinationalChemodynamic-Photodynamic Therapy,ACS Nano 2024, 18, 17837−17851. ...
[1] Ling-Hong Xiong, Langyi Yang, Jiangtao Geng, Ben Zhong Tang, and Xuewen He, All-in-One Alkaline Phosphatase-Response Aggregation-Induced Emission Probe for Cancer Discriminative Imaging and CombinationalChemodynamic-Photodynamic Therapy,ACS Nano 2024, 18, 17837−17851. ...
[1] Ling-Hong Xiong, Langyi Yang, Jiangtao Geng, Ben Zhong Tang, and Xuewen He, All-in-One Alkaline Phosphatase-Response Aggregation-Induced Emission Probe for Cancer Discriminative Imaging and CombinationalChemodynamic-Photodynamic Therapy,ACS Nano 2024, 18, 17837−17851. ...
研究人员与巴塞罗那生物医学研究所(IRB Barcelona)和巴塞罗那自治大学(UAB)的科学家们合作,在《NatureNanotechnology》杂志上发表了一篇题为“Urease-powered nanobots for radionuclide bladder cancer therapy”的论文,报告了他们用放射性碘化纳米机器人进行的小鼠试验。在他们的报告中,研究小组总结道:“这些结果使我们向转...