CD8 T cells play a crucial role in immune responses to virus infections and tumors. Nave CD8 T lymphocytes after TCR stimulation undergo differentiation into CTLs and memory cells, which are essential sources of IFN-纬. We investigated IFN-纬 production by CD8 T cell subsets found in non...
cells and CD19+CD4–CD8–CD45.1–CD45.2+CFSEhighcontrol B cells were sorted on a FACSAria and resuspended in DMEM 2%. Within each experiment, the same number of inactivated or naive B cells (4–7 × 103) were transferred i.v. to 2° recipients, which were re-immunized with 50 μ...
CD8 T cells induce LN-like vasculature in i.p. tumours. To elucidate mechanisms underlying the development of LN-like vasculature in tumours, we investigated whether immune cell subsets were involved. Infiltration of transferred naive OT-I and naive polyclonal T-cells into i.p. tumours growing ...
CD8 Tcellsinterferon‐γvirtual‐memory cellsCpG methylationantigen‐inexperienced memory CD8 TcellsCD8 T cells play a crucial role in immune responses to virus infections and tumors. Nave CD8 T lymphocytes after TCR stimulation undergo differentiation into CTLs and memory cells, which are essential ...
IL-2–anti–IL-2 complex–driven memory-like CD8+ T cells had incomplete cellular fitness compared with antigen-driven memory cells regarding homeostatic turnover and cytokine production. These results suggest that intense IL-2 signals, with limited contribution from the TCR, program the ...
Antiviral CD8+ T cells cause an ex- perimental autoimmune encephalomyelitis-like disease in naive mice. J. Neurovirol. 18, 45-54.Libbey JE, Cusick MF, Tsunoda I, Fujinami RS: Antiviral CD8(+) T cells cause an experimental autoimmune encephalomyelitis-like disease in naive mice. J Neuro...
We have found that naive T cells express the highest levels of LAIR-1, even more than memory cells. The cross-linking of LAIR-1 inhibits T cell receptor (TCR) mediated signals in freshly isolated human naive T cells and whole populations of CD4+ or CD8+ T cells. TCR cross-linking ...
Thus, a subset of dysregulated CD4+ T cells can cause tissue alterations seen in psoriasis without the presence of CD8+ cells or a primary epithelial abnormality.doi:10.1038/nm0297-183Sch?n, Michael P.Detmar, MichaelParker, Christina M....