The ansamycin class of antibiotics are produced by various Actinomycetes. Their carbon framework arises from the polyketide pathway via a polyketide synthase (PKS) that uses an unusual starter unit. Rifamycin (rif), produced by Amycolatopsis mediterranei, is the archetype ansamycin and it is ...
On the structure of alisamycin, a new member of the manumycin class of antibiotics. Chatterjee,E K,Vijayakumar,... - 《Journal of Antibiotics》 被引量: 8发表: 1993年 On the structures of alisamycin, a new member of the manumycin class of antibiotics. CHATTERJEE,SUGATA,VIJAYAKUMAR,... -...
The ansamycin class of antibiotics are produced by various Actinomycetes. Their carbon framework arises from the polyketide pathway via a polyketide synthase (PKS) that uses an unusual starter unit. Rifamycin (rif), produced by Amycolatopsis mediterranei, is the archetype ansamycin and it is medicall...
The ansamycins constitute a class of antibiotics characterized by an aliphatic bridge linking two non-adjacent positions of an aromatic nucleus. The name, originally suggested by Prelog , is derived from the term "ansa compounds" coined by Lüttringhaus in 1942 ( 71 ). It is the structures ...
elomycin are herein confirmed through total synthesis. Careful titration of the synthetic products reveals that kibdelomycin is the salt form of amycolamicin. This synthesis employs a highly convergent strategy, which provides a modular approach for further SAR studies of this class of antibiotics....
elomycin are herein confirmed through total synthesis. Careful titration of the synthetic products reveals that kibdelomycin is the salt form of amycolamicin. This synthesis employs a highly convergent strategy, which provides a modular approach for further SAR studies of this class of antibiotics....
In class II HKs, the phosphorylated histidine is remote from the CA domain and is located in the histidine-containing The Journal of Antibiotics phosphotransfer domain4 (Supplementary Figure S1B). The cytoplasmic regions of HKs from E. coli and S. mutans were cloned, expressed and purified, ...
A concise, highly convergent total synthesis of saptomycin B, a member of the pluramycin class of antitumor antibiotics, is reported. The target compound was assembled from four building blocks (a tricyclic platform, two sugars, and an alkynal) in 15% yield through 10 synthetic operations. Th...
Twitter Google Share on Facebook sideromycin [sid″er-o-mi´sin] any of a class ofantibioticsthat are synthesized by certainactinomycetesand inhibit bacterial growth by interfering with iron uptake. Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. ...
The prescription of this class of antibiotics should be avoided in combination with VPA. Nevertheless, this combination may be helpful to reduce toxic VPA levels intentionally. The antibiotic Meropenem is particularly efficient in treating VPA overdose-mediated toxicity combined with levocarnitine (Dreuc...