Here, we show that MYC transcriptionally activates IDH2 and increases alpha-ketoglutarate (αKG) levels. This regulatory step induces the activity of αKG-dependent DNA hydroxylases and RNA demethylases, thus reducing global DNA and RNA methylation. MYC, in a IDH2-dependent manner, also promotes...
Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors Genes Dev., 26 (2012), pp. 1326-1338 CrossrefView in ScopusGoogle Scholar Xu et al., 2011 W. Xu, H. Yang, Y. Liu, Y. Yang, P....
Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase-alpha and therapeutic targeting. Blood Cancer J 2015; 5: 287. Article CAS Google Scholar Shalapour S, Karin M . Fatty acid-induced T cell loss greases liver carcinogenesis. Cell Metab 2016; 23: 759–761. Article ...
Dysregulated choline metabolism in T-cell lymphoma: role of choline kinase-alpha and therapeutic targeting. Blood Cancer J 2015; 5: 287. 15 Shalapour S, Karin M. Fatty acid-induced T cell loss greases liver carcinogenesis. Cell Metab 2016; 23: 759–761. 16 Kong W, Wei J, Abidi P, ...
(SAH), which if accumulated, is a potent inhibitor of methyltransferases27. MYC also enhanced the levels of alpha-ketoglutarate (αKG), a critical co-factor for histone demethylation mediated by Jumonji Domain-containing Histone Demethylases (JHDM)28. Thus, these results suggest that histone ...
TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. J Biol Chem. 2004;279:27781–9. Article CAS Google Scholar Zhang Y, Chen L, Yang S, Fang D. E2F1: a potential negative regulator of hTERT transcription in normal cells upon ...
The diagnosis of NAFLD-cirrhosis and NAFLD-HCC was based on exclusion of other common causes of cirrhosis and liver disease (viral hepatitis, alcoholic consumption >20 g/day for men and >10 g/day for woman, Wilson’s disease, autoimmune, alpha-1-antitrypsin deficiency and drug-induced liver ...
在本实验中,给予小鼠300 mg/kg(称为再生剂量)APAP后,小鼠出现了明显的肝损伤,但由于肝脏再生能力强可以最终恢复。给予小鼠600 mg/kg剂量(称为非再生剂量),也引起了明显的肝损伤,但将导致相当大的再生延迟。血清ALT水平表明,在APAP给...
Phosphocholine (PC), which is synthesized by choline kinase alpha (CHKA) catalysis, is upregulated in EC tumor tissues. The present study aimed to investigate the effect of PC accumulation on EC cells and clarify the relationship between PC accumulation and c-Myc activity in EC. Methods The ...
The transcriptional role of cMyc (or Myc) in tumorigenesis is well appreciated; however, it remains to be fully established how extensively Myc is involved in the epigenetic regulation of gene expression. Here, we show that by deactivating succinate dehy