multi-ancestry eQTL meta-analysis to increase power and fine-mapping resolution. Analysis of 3,983 RNA-sequenced samples from 2,119 donors, including 474 non-European individuals, yielded an effective sample size of 3,154. Joint statistical fine-mapping of eQTL and GWAS identified 329 ...
Although this is a large multi-ancestry PD meta-analysis GWAS, the European population is still overrepresented. Around 80% of full PD cases are of European descent. Individuals of African descent were particularly underrepresented at just 0.5% of the effective PD cases. The discoveries in our st...
meta-analysis were also significant in the multi-ancestry results after multiple test correction: 'curated geneset: Ikeda MIR30 Targets Up' (PFDR = 0.018) and 'cellular component: vacuolar membrane' (PFDR = 0.047). In addition, ontology terms in immune system pathways (microglial ...
Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus Asma A Elashi Salman M Toor Omar M E Albagha BMC Medical Genomics(2024) Maternal smoking, nutritional factors at different life stage, and the risk of incident type 2 dia...
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet. 2016;48:1162–70. Article CAS PubMed PubMed Central Google Scholar Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, et al. Trans-ancestry meta-...