The role of the open reading frame and its sequence composition has recently emerged as equally important in the control of gene expression as that of the 5′ and 3′UTRs, which have traditionally been seen as the regulatory hubs of the mRNA. More specifically, codon usage has been highlight...
This is the primary event in the mRNA decay pathway followed by the removal of the 5′ cap and subsequent degradation of the target mRNA [27, 34,35,36,37]. Deadenylation requires the expulsion of the poly(A)-binding protein (PABP), which is thought to play an important role in the ...
The mRNA 5′ cap-binding protein eIF4E and control of cell growth 10.1016/S0955-0674(98)80150-6 View PDF View article Google Scholar [27] U. Sahin, K. Karikó, Ö. Türeci mRNA-based therapeutics—developing a new class of drugs ...
mRNA cap regulation in mammalian cell function and fate 2019, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms Show abstract Impaired ribosome biogenesis: Mechanisms and relevance to cancer and aging 2019, Aging Translation deregulation in human disease 2018, Nature Reviews Molecular Cell Biology...
(m7GpppNm) was used. The half-life of mRNA is also increased as a result of a synergistic effect of 5′ end cap and 3′ end poly(A) tail [120]. Another peptide chain, the signal peptide was obtained from the tPA ofH. sapienswhich can improve the immunogenicity of the vaccine [121...
Strikingly, ring-type polysomes were equally observed on synthetic mRNAs that lacked a poly-A tail or 5′-cap, suggesting a distinct or more general mechanism of mRNA circularization (Afonina et al., 2015). As translation initiation occurs at the 5′-end of the mRNA and ribosome recycling ...
新冠疫苗的研发路径问题的提出在没有特效药的情况下,人们把目光投向疫苗,钟南山说“疫苗是解决新冠肺炎最根本的东西,最终形成群体免疫是靠疫苗”。中国医学科学院医学实验动物研究所研究员秦川表示,在国内,科技攻关组同步部署了5条技术路线进行疫苗研发,目前已有8种疫苗...