Liver injury, egg granuloma and fibrosis, and adaptive immune response were detected to evaluate the effect of portal vein injection of eggs while inducing mouse model of schistosomiasis liver disease. Results The results showed that significant egg granuloma...
The cells were delivered into the liver through the portal vein by intrasplenic injection, and NTBC (2-[2-nitro-4-(trifluo- romethyl)benzoyl]cyclohexane-1,3-dione, also known as Nitisinone) was withdrawn from the drinking water one day after surgery. Non-transplanted mice were fed ...
2 = perisinusoidal/pericellular and portal/periportal fibrosis (with dense collagen deposits around the portal vein), 3 = bridging fibrosis (where mature fibrous tissue forms a band connecting the portal area to the central vein), and 4 = cirrhosis (characterized by nodules of cells surrounded ...
Here, we present a protocol to generate a murine model of liver metastasis by directly injecting tumor cells into the portal vein under ultrasound guidance. We describe steps for animal and cell preparation and two techniques for injecting tumor cells. One technique is freehand while the other te...
Approximately 10–25% of CRC cases exhibit notably high metastatic potential at the time of initial diagnosis, and almost 70% of CRC cases are prone to metastasize to distant sites during the entire treatment process, especially the liver, owing to the blood flow system of the portal vein [4...
The response of adult unirradiated F1hybrid miceto the injection of parentalT cellsdepends upon differences in the donor and hostmajor histocompatibility complex(MHC), and donor cell inoculum size and T-cell phenotype. The administration of donor cells that differ from the F1recipient at both class...
derived tumor metastasis in male and female mice.Method and Result: 4T1-Luc breast cancer cells were implanted in male and female Balb/c mice via various routes, including inguinal fat pad injection, tail vein injection, caudal artery injection, portal vein injection, and Intratibial Injection. ...
b, Incidence of lung metastasis after tail vein injection of MSS or MSI gastric cancer cells into immunocompetent (C57BL/6) or immunodeficient (R2G2) mice. Exact numbers of independent mice are indicated on each bar. c, H&E staining of lungs isolated from mice in b. Representative of n...
The present study used human immunodeficiency virus (HIV)-based lentiviral vectors containing an EF1a enhancer/promoter driving human fac- tors VIII (hFVIII) or IX (hFIX) complemen- tary DNA expression for portal vein injection into C57Bl/6 mice. Increasing doses of hFIX-expressing lentivirus ...
with the bulk of LDs being localized in hepatocytes around the central vein of the liver lobule. Using spatial transcriptomics we explored the age-dependent changes that occur within the central to portal axis of the liver lobule. Interestingly, we identified members of the Cide gene family to ...