Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have been generated, a consensus on pancreatic cell states in development, homeostasis and diabetes as well as the value of preclinical animal models is missing. Here, we present an scRNA-seq cross-condition mouse is...
Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have been generated, a consensus on pancreatic cell states in development, homeostasis and diabetes as well as the value of preclinical animal models is missing. Here, we
Heemskerk MH, Blom B, Nolan G et al (1997) Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3. J Exp Med 186:1597–1602 doi:10.1084/jem.186.9.1597 PubMedCASGoogle Scholar Ikawa T, Fujimoto S, Kawamoto H et al (...
CELL BEHAVIORS AND MOLECULAR MECHANISMS DIRECTING GUT ENDODERM MORPHOGENESIS IN THE MOUSE EMBRYOKwon, Gloria Soo Jin
The Wnt family and associated canonical signaling cascades have the ability to affect development via multiple mechanisms including regulating cell fate, migration, and cell growth/survival. The authors present evidence that Wnt and Dkk are acting as guidance cues, balancing attractive and repulsive sign...
As developing tissues grow in size and undergo morphogenetic changes, their material properties may be altered. Such changes result from tension dynamics at cell contacts or cellular jamming. Yet, in many cases, the cellular mechanisms controlling the ph
Correction to: 鈥楧evelopmental plasticity, cell fate specification and morphogenesis in the early mouse embryo鈥 Over the past two decades, our understanding of mouse development from implantation to gastrulation has grown exponentially with an upsurge of genetic, molecular, cellular, and morphogenetic ...
Ocular lens development has been extensively studied to address the molecular mechanisms that control tissue-specific, temporal and spatial gene regulation [2, 3]. The mammalian lens is composed of two cell types, the anterior proliferating lens epithelial cells and the posterior differentiating lens ...
B Arrow indicates the results of clicking on a cell for a disease term showing specific disease annotations at the gene level for human and at the genotype level for the mouse. The “Find Mice” button is a link to the International Mouse Strain Resource (IMSR) (Eppig et al. 2015b) ...
Waddington’s epigenetic landscape is a metaphor frequently used to illustrate cell differentiation. Recent advances in single-cell genomics are altering our understanding of the Waddington landscape, yet the molecular mechanisms of cell-fate decisions r