T.S. conceived the manuscript. T.S. and S.P.-L. contributed to the writing and revision of the manuscript. Corresponding author Correspondence toTamar Schlick. Ethics declarations Competing interests The authors declare no competing interests. ...
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While blood clot formation has been relatively well studied, little is known about the mechanisms underlying the subsequent structural and mechanical clot remodeling calledcontractionorretraction. Impairment of the clot contraction process is associated with both life-threatening bleeding and thrombotic conditi...
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In malignancy, CAF subtypes contribute to cancer metastasis by promoting tumor cell proliferation and/or activating ECM remodeling causing a stiffer ECM that induces tumor cell migration [17,18]. Specifically, CAFs can be activated by PDAC cells to express type I collagen, and subsequently activate...
To assess if electrostatic forces drive the process of extravasation of EPCs, we investigated in vitro EC adhesion and spreading in the absence or in the presence of cytoskeleton remodeling. To this aim, ECs were plated on fibrinogen (FG) or on a positively charged synthetic polymer of L-lysin...
To gain further insights into the chromatin remodeling of mESCs during differentiation (Otterstrom et al., 2019;Ricci et al., 2015), we simulated chromatin fibers typical of mESCs and mNPCs (Figures 1andS1) using our nucleosome-resolution chromatin mesoscale model (Bascom et al., 2016). The...
These pathways are known to promote myocardial fibrosis and cardiac remodeling, contributing to the progression of heart failure [44,45,46,47], respectively. Additionally, conditions such as Cushing syndrome, circadian disruption, and cardiomyopathy, which are associated with increased myocardial fibrosis...
consequently, impaired functions [41]. With age-associated changes, microglia become less efficient at surveying the brain parenchyma, remodeling synapses, and clearing away damaged cells and toxic debris [42]. Other myeloid cells include monocytes and macrophages, specialized innate immune cells responsi...
, other cell types are also involved in the bone healing/remodeling process, such as resident and infiltrating immune cells that exert pro- and anti-inflammatory activities depending on environmental cues1,8,9,10. This is evidenced by the fact that acute pro-inflammatory factor administration (e...