Leukaemias with translocations involving MLL have a unique clinical and biologic profile and are often associated with poor prognosis. MLL rearrangements occur in 70+% of infant leukaemias, but are less frequent in leukaemias in older children; MLL translocations occur in ± 10% of AMLs in adults...
本组MLL-r ALL和MLL-r AML患儿EFS和OS率均低于本中心前期研究中ALL和AML患儿5年的EFS率(74.8%和56.5%)和OS率(82.6%和69.6%)[4-5],同时本组MLL-r AML患儿2年EFS率也低于本中心前期研究中M4/M5患儿3年EFS率(51.9%)[19],提示M4/M5伴有MLL-r可能是儿童AML预后更差的因素。 目前已被证明发病时的年龄、...
重排阳性AML患者预后的危险因素.%Objective To investigate the prognosis of allogeneic hematopoietic stem-cell transplantation (allo-HSCT) for patients with acute myeloid leukemia and MLL rearrangement.Methods From September 2009 to May 2016,the clinical data of 47 patients with MLL-rearranged AML ...
中文摘要MLL基因重排阳性急性髓系白血病的临床特点与预后分析复发,复发率21.6%。可见MLL基因重排阳性AML患者较对照组患者缓解率低,易复发(P<O.05)。(2)至随访截止时MLL基因重排阳性AML患者有14例存活,37例死亡,其中移植后存活6例,单纯化疗存活8例,OS为32.3%。对照组患者中有29例存活,22例死亡,其中移植后存活14...
MLL-r B-ALL 最常见的重排为MLL-AF4重排；MLL-r AML 最常见重排为MLL-AF9和MLL-AF6重排。单纯化疗复发率高，异基因造血干细胞移植可以显著改善患者预后（P < 0.05）。此外，多因素回归分析影响患者总生存期（OS ）的因素，诊断时白细胞计数≥100×109/L （HR =8.030，95%CI ： 1.327~48.594，P ...
本次APBMT大会上,高博医学(血液病)北京研究中心北京高博博仁医院吴彤主任、赵永强医生团队王睿医生报告了“Allogeneic Hematopoietic Stem Cell Transplantation Improves the Poor Prognosis in MLL-AF6 Positive Acute Myeloid Leukemia”(allo-HSCT改善MLL-AF6阳性AML患者不良预后),【摘要号187】。
[3]E M Heath,S M Chan,M D Minden,T Murphy,L I Shlush,A D Schimmer. Biological and clinical consequences of NPM1 mutations in AML[J]. Leukemia,2017,31(20): [4]DUPLOYEZ N, WILLEKENS C, MARCEAU-RENAUT A, et al. 2015. Prognosis and monitoring of core-binding factor acute myeloid...
Pui, C. H. & Campana, D. Age-related differences in leukemia biology and prognosis: the paradigm of MLL-AF4-positive acute lymphoblastic leukemia.Leukemia21, 593–594 (2007). ArticleCASPubMedGoogle Scholar Felix, C. A. Secondary leukemias induced by topoisomerase-targeted drugs.Biochim. Biophys...
Acute lymphoblastic leukemia (ALL) in infants (< 1 year) is characterized by a poor prognosis and a high incidence of MLL translocations. Several studies d... RW Stam,P Schneider,JAP Hagelstein,... - 《Blood》 被引量: 227发表: 2010年 Identification of the novel AML1 fusion partner gene...
such, when expressed in the naturally-existing, rapidly-cycling immature myeloid progenitors, this cell state becomes perpetuated, yielding malignancy. In humans, highCCND1expression predicts worse prognosis for MLL fusion AMLs. Our work elucidates one of the earliest steps toward malignancy and ...