mir-135a是mirna家族的常见成员,已有研究显示了其在nsclc中的失调情况。因此,mir-135a在nsclc组织中的表达显著下调,而其恢复表达可降低肺癌细胞的迁移和侵袭能力。mir-135a可能在非小细胞肺癌中发挥抑癌作用。 4、相关研究表明,与健康个体相比,nsclc患者血清中mir-135a的水平显著降低,并与疾病进展密切相关,血清mir-...
基于此,为明确miR-135a-5p介导AD突触紊乱的直接靶点,研究人员通过多个数据库对比发现四个潜在候选分子(Rock1、Rock2、Cacna1d和Pik3r2),而在APP/PS1小鼠中只有Rock2(Rho关联卷曲螺旋蛋白激酶2)发生显著上调变化(图5a),提示了Rock2是介...
高孕酮环境下miR-135a与HOXA10 mRNA结合调节胚胎着床因子ITGβ3和EMX2(Binding of microRNA-135a (miR-135a) to homeobox protein A10 (HOXA10) mRNA in a high-progesterone environment modulates the embryonic implantation factors...
目前对mir-135a研究主要集中在肿瘤成长和神经系统病变,研究结果表明,mir-135a通过调控不同靶基因参与细胞凋亡通路的调控,从而影响肿瘤细胞的存活,但mir-135a对心纤维化的调控尚无报道,对纤维化相关通路的影响亦无研究。 技术实现要素: 发明目的:本发明目的在于针对现有技术的不足,确定mir-135a在trpm7介导的心肌纤维...
Aberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of Alzheimer’s disease (AD), but most abnormally expressed miRNAs found in AD are not regulated by synaptic activity. Here we report that dysfunction of miR-135a-5p/Rock2/
Upregulating miR-135a-5p also reduced infarct volume and neuronal pyroptosis, while improved neurological scores in MCAO/R mice. Co-IP confirmed protein interaction between DDX3X and NLRP3 in CIRI models. Furthermore, miR-135a-5p mimics alleviated pyroptosis and inhibited DDX3X/NLRP3 pathway ...
Enforced miR-135a expression sensitized lung cancer cells to cisplatin-induced apoptosis by targeting MCL1, and paclitaxel resistance of non-small cell lung carcinoma cell is associated with the up-regulation of miR-135a [11], [12]. Krüppel-like factor 8 (KLF8) belongs to the Krüppel-like...
在宫颈癌中miR-135a-5p表达水平与临床分期、淋巴结转移有关(P < 0.05);GATA3 mRNA的表达与临床分期、肌层浸润深度及淋巴结转移均有关(P < 0.05)。 结论 宫颈癌中miR-135a-5p和STAT3表达上调,GATA3表达下调,三者可能通过相互作用参与宫颈癌的发生、发展。 关键词: 宫颈癌 / 微小RNA-135a-5p / GATA结合...
循环miR-135a水平与HDL抗氧化功能的关联性