To assess if the absence of fever (normothermia: 36.0-38.0掳C) is an independent prognostic factor, we computed multiple Cox regression analyses, adjusted for different potential confounders. Results 1,901 patients with infection, treated with antibiotics within 24 hours after arrival, were included...
in particular those arising from the emergence of multidrug-resistant pathogenic bacteria. This has prompted significant efforts in the development of new small molecule antibiotics1,2,3,4, resulting in a resurgence of interest in natural product research to discover selective, novel mode-of-action t...
Almost 30% of the children were treated with antibiotics prior to hospitalisation compared with 2.5% of the adults. The mean PORT score at admission was calculated in the entire adult group except for one case in which some data were unavailable. No cases were in PORT class I as these ...
Elsamicins A and B, new antitumor antibiotics related to chartreusin: 2. Structures of elsamicins A and B. Sugawara,K,Tsunakawa,M,Konishi,M,Kawaguchi,H,Krishnan,B,Cunheng,H,Clardy,J. Journal of Organic Chemistry . 1987Konishi M,Sugawara K,Tsunakawa M, et al.Elsamicins A and B, ...
Convergent and rapid assembly of benzonaphthopyranone cores of chartreusin, chrymutasins and hayumicinsAntibioticsHauser–Kraus annulationBenzonaphthopyranonesNatural productsTotal synthesisA new methodology for the rapid regiospecific synthesis of benzonaphthopyranones has been developed, on the basis of ...