Metformin and vitamin B12 deficiencyWainwright, PatrickDiabetes & Primary CareGilligan MA. Metformin and vitamin B12 deficiency. Arch Intern Med 162: 484-485, 2002.
After six months of rehabilitation, he could walk independently with a stick but there was persistent lower-limb ataxia and sensory deficits (with residual high T2 signal). This patient had multiple risk factors for developing B12 deficiency: vegetarianism, age, diabetes mellitus and Metformin use....
The majority of the women had not had their B12levels measured. However, upon testing, almost 1 in 10 were found to have a B12deficiency. Although metformin is recommended for the first-line treatment of type 2 diabetes, it is associated with vitamin B12deficiency, which itself increases the ...
For one, metformin is known to interfere with the absorption of B12, and a vitamin B12 deficiency can cause a variety of symptoms, such as fatigue, headaches, and depression. Additionally, the deficiency can also increase the risk of anemia. As such, individuals using metformin should regularly...
We report two cases who had symptomatic vitamin B12 deficiency related to metformin use; the mechanisms are discussed. The clinician must be aware of the possibility of metformin-associated B12 deficiency in users who suffer cognitive impairment, peripheral neuropathy, subacute combined degeneration of ...
Metformin and vitamin B12 deficiency Comment on Tidsskr Nor Laegeforen. 2007 Jan 4;127(1):65. JS Scozzari - 《Archives of Internal Medicine》 被引量: 89发表: 2002年 Miglitol, an α-glucosidase inhibitor, prevents the metformin-induced fall in serum folate and vitamin B12 in subjects with ...
Our companion article outlines how metformin use can lead to a clinically significant deficiency in vitamin B12, and describes the problems this can cause. In this comment, we outline a project conducted in four primary care practices that aimed to improve metformin-relat...
维生素B12、叶酸严重缺乏者慎用 需额外说明的是,二甲双胍本身对肝脏及肾脏无毒性,但肝肾功能受损会明显延长药物的清除期,导致血浆二甲双胍浓度上升,增加乳酸性酸中毒风险。 派派的建议是:肝功能异常者不建议服用。当肾小球滤过率(eGFR)≥60ml/(min·1.73m2)可正常服用;eGFR为45～59ml/(min·1.73m2)时,推荐低剂...
Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy;Daryl J Wile, Cory Toth; Diabetes Care 2010 Risk Factors of Vitamin B12 Deficiency in Patients Receiving Metformin;Rose Zhao-Wei Ting et al; Arch Intern Med. 2006;166(...
Presents information on a study which determined the magnitude and mechanism of the reduction in serum vitamin B12 after metformin administration. Research... Bauman,William,A.,... - 《Diabetes Care》 被引量: 335发表: 2000年 Association of biochemical B deficiency with metformin therapy and vitami...