Metformin-associated vitamin B12 deficiency is a well-established side effect, especially in patients taking higher doses of metformin or who have existing risk factors. Severe deficiency causes a wide range of systemic disorders. Gait instability, which leads to frequent falling, is ...
We report two cases who had symptomatic vitamin B12 deficiency related to metformin use; the mechanisms are discussed. The clinician must be aware of the possibility of metformin-associated B12 deficiency in users who suffer cognitive impairment, peripheral neuropathy, subacute combined degeneration of ...
After six months of rehabilitation, he could walk independently with a stick but there was persistent lower-limb ataxia and sensory deficits (with residual high T2 signal). This patient had multiple risk factors for developing B12 deficiency: vegetarianism, age, diabetes mellitus and Metformin use....
The majority of the women had not had their B12levels measured. However, upon testing, almost 1 in 10 were found to have a B12deficiency. Although metformin is recommended for the first-line treatment of type 2 diabetes, it is associated with vitamin B12deficiency, which itself increases the ...
Some studies found negative or neutral effects for metformin use by people with diabetes; the potential mechanism of metformin-induced vitamin B12 deficiency is discussed. Conclusions: Metformin should continue to be used as a first line therapy for diabetes in patients at risk of developing dementia...
Metformin: Vitamin B12 deficiency and peripheral neuropathy: case report
Our companion article outlines how metformin use can lead to a clinically significant deficiency in vitamin B12, and describes the problems this can cause. In this comment, we outline a project conducted in four primary care practices that aimed to improve metformin-relat...
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Metformin mechanism of action: Decreases hepatic gluconeogenesis: metformin reduces glucose production by 25–40%. Improves peripheral insulin sensitivity thus improving glucose utilization. Metformin increases insulin-mediated glucose uptake into muscle cells and glucose utilization by 20–50%. Skeletal muscle...
Metformin use is associated with a vitamin B12 deficiency. The influence of both duration and dose of metformin use on vitamin B12 deficiency is unclear. Mostly total vitamin B12 is used as a marker for vitamin B12 deficiencydoi:10.1007/s12467-014-0053-yHart, Huberta E....