Background & objectives: Resistances to carbapenem group of antimicrobials among Escherichia coli due to production of carbapenemases, especially the New Delhi metallo-beta-lactamase (NDM) types, pose serious challenges in the treatment of infections in healthcare settings. This study was undertaken to...
The first β-lactamase was described as a “penicillinase” capable of hydrolyzing penicillin in Escherichia coli in 1940, about the same time as the first clinical use of penicillin was reported in the literature.43 The next years witnessed the rapid spread of plasmid-encoded ...
VIM-1 is a new group 3 metallo-β-lactamase recently detected in carbapenem-resistant nosocomial isolates of Pseudomonas aeruginosa from the Mediterranean area. In this work, VIM-1 was purified from an Escherichia coli strain carrying the cloned bla VIM-1 gene by means of an anion-exchange chro...
To collect clinical inpatients with the Klebsiella pneumoniae,Escherichia coli and Proteus producing ESBLs;through modified Hodge test and EDTA double disk ... XJ Feng,Y Zhang,Y Luo - 《Chinese Journal of Nosocomiology》 被引量: 14发表: 2010年 加载更多来源...
Conjugation experiments were unsuccessful in transferring the beta-lactamase determinant to Escherichia coli or Pseudomonas aeruginosa. Macrorestriction analysis by pulsed-field gel electrophoresis demonstrated that the isolates were of clonal origin. PCR mapping and sequencing of the variable region of the ...
New Delhi Metallo Beta Lactamase-1 (NDM-1) is a novel beta -lactamase enzyme that is ubiquitously found in Escherichia coli. This enzyme belongs to a B1 subclass of Metallo Beta Lactamases and is known to induce resistance to standard intravenous antibio
After expression in Escherichia coli, it was found to hydrolyse nitrocefin, a beta-lactam, and penicillin G. This was inhibited by sulbactam, a beta-lactamase inhibitor. In addition, the tupanvirus MBL fold-protein was not active on single- or double-stranded DNA, but degraded RNAs from ...
Effect of Subinhibitory Concentrations of Antibiotics on Intrachromosomal Homologous Recombination in Escherichia coli Subinhibitory concentrations of some antibiotics, such as fluoroquinolones, have been reported to stimulate mutation and, consequently, bacterial adaptatio... E Lopez,J Blazquez - 《Antimicrob...
The consumption of milk contaminated with antibiotic-resistant bacteria poses a significant health threat to humans. This study aimed to investigate the prevalence of Enterobacteriaceae producing β-lactamases (ESBL, MBL, and AmpC) in cow and buffalo mil
coli.Nowadays, resistance power of the organism is developing which may be innately acquired during their lifecycle.The emergence of beta鈥搇actamase and metallo-beta-lactamase is an important mechanism that makes bacteria more resistant to antibiotics as these enzymes hydrolyze the antibiotics. ...