& Werb, Z. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell 16, 225–238 (2015). CAS PubMed PubMed Central Google Scholar Gonzalez, H., Hagerling, C. & Werb, Z. Roles of the immune system in cancer: from tumor ...
that regulate cancer cell proliferation. A new study identifies aldolase A as a critical node that, when inhibited in cancer cells, turns glycolysis into an ATP-consuming process. Targeting aldolase A to induce imbalanced glycolysis could overcome the intrinsic metabolic plasticity of cancer cells. ...
Since tumor cells show sensitivity to the ionizing radiation (IR), radiotherapy emerged as the main type of cancer treatment [1,2,3]. Radiotherapy directly induces DNA damage or indirectly induces the production of reactive oxygen species (ROS) in cancer cells. Additionally, radiotherapy combined ...
of glucose-derived carbons in cancer cells, resulting in increased glycerophospholipids and triacylglycerol synthesis. The knockdown of HIF1α or G3P acyltransferase 3 (a regulatory enzyme of glycerophospholipid synthesis) reduced metastasis in xenograft models of OvCa. In summary, we show that, in ...
Cancer MetabolismSection edited by Violena Pietrobon and Mia Stanic Tumor cells reprogram nutrient acquisition and metabolic pathways to support abnormal growth and metastasis, a dysfunctional process that is a hallmark of cancer. The Cancer Metabolism section will offer a solid framework to promote ...
responding immune cells, metabolic heterogeneity and plasticity may serve to distinguish the two. As such, understanding the differential metabolic requirements of the diverse cells that comprise an immune response to cancer offers an opportunity to selectively regulate immune cell function. Such a ...
5、The glucose/NSUN2/TREX2 axis restricts cytosolic dsDNA accumulation for cGAS/STING activation to maintain oncogenic activity of cancer cells 与其同家族蛋白TREX1类似,TREX2可以切割降解单链和双链DNA。已知TREX1可以通过清除胞浆DNA抑制cGAS/STING信号通路,进而促进肿瘤进展(对cGAS/STING信号通路感兴趣的同学...
The stromal vasculature in tumors is a vital conduit of nutrients and oxygen for cancer cells. To date, the vast majority of studies have focused on unraveling the genetic basis of vessel sprouting (also termed angiogenesis). In contrast to the widely st
这篇文章由中国孙宇团队于2023年10月发表在Nature Metabolism（IF=20.8，PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy），是一篇探究肿瘤微环境衰老基质细胞间接调控肿瘤细胞功能及其机制的文章，其行文逻辑、研究结论以及将肿瘤里的研究结论延伸到生理性衰老的想法...
the metabolism of cancer cells is altered compared to that of cells that grow normally. Cancer cells use this metabolism to provide molecular building blocks and to meet their high energy needs. It has also been known for some time