The tumor cell has a very distinctive metabolism. It acts as a metabolic trap for host nutrients thus taking vital compounds for the metabolism of the host. Depending on the particular tumor growing pattern, cancer cells use preferentially glucose or amino acids for their energetic or biosynthetic ...
Here, we describe key features of the metabolic transformation of cancer cells, which frequently include the switch to aerobic glycolysis, a profound mitochondrial reprogramming, and the deregulation of lipid metabolism, highlighting the notion that these pathways are not independent but rather cooperate ...
Hypoxia results in lactate accumulation and H+ build-up, which alter the metabolic pathways of cancer cells and promote tumor metastasis [105]. Lactate activates the expression of the SLC1A5 and GLS1 to promote glutamine transport and catabolism, which provides substrates for the TCA cycle [32]...
c, Gene scores of untreated (x-axis) and erastin-treated (3 µM, y-axis) Jurkat cells. d, Significantly enriched pathways (REACTOME) represented within the top 50 most essential genes in the low dose erastin screen. e, Significantly enriched pathways (REACTOME) represented within the top...
As such, cancer cells support high ATP turnover to construct the building blocks needed to fuel neoplastic growth. The coordination of metabolic networks in malignant cells is dependent on the collaboration with cellular signaling pathways. Glycogen synthase kinase 3 (GSK3) lies at the convergence ...
Cancer stem cells (CSC) are the minor population of cancer originating cells that have the capacity of self-renewal, differentiation, and tumorigenicity (when transplanted into an immunocompromi
Kung, C. et al. Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.Chem. Biol.19, 1187–1198 (2012). CASPubMedPubMed CentralGoogle Scholar Palsson-McDermott, E. M. et al. Pyruvate kinase M2 is required for the expression of the immune checkpoint PD-L1 in immune...
A central aim of the field of cancer metabolism is to identify metabolic pathways selectively activated in tumor cells, which likely include crucial biosynthetic pathways, to reveal therapeutic targets [14,15]. To accomplish this task, it is necessary to quantify differences in metabolic flux between...
Among the latter we could mention: the significant changes of pH and redox potential inside and outside the tumor cells, their energy generating pathways relying on aerobic glycolysis, glutaminolysis or fatty acid oxidation, the activation of the NADPH:quinone-oxidoreductases, as well as the high ...
The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance In order to adapt to a higher proliferative rate and an increased demand for energy sources, cancer cells rewire their metabolic pathways, a process curren... B Polonia...