Somewhat confounding efforts to elucidate the cause of meningioma is a lack of universal agreement on the cell of origin for all meningiomas. Most meningiomas likely arise from mesodermal arachnoid cap cells normally found at the apex of arachnoid granulations. 1,2 Cleland, in 1846, is credited ...
Also, in the series of Kim et al., the unusual histopathology as well as the unequivocal brain invasion led to erroneous diagnoses in all of their 5 cases. The diagnoses run a spectrum of malignant meningioma, ganglioglioma, fibrous meningioma, fibrous nodule, and a plasma cell granuloma [8]...
The authors identify PGDS + arachnoid cells as a cell of origin for meningiomas [29]. Also of great interest are the tumor suppressor genes CDKN2A/B (located at 9p21 in humans). In meningiomas, alterations of CDKN2A/B are more common in higher grade tumors and are associated with ...
This concept resolves the controversy about their cell of origin, explains their occurrence in various locations within as well as outside the neuraxis, and provides an explanation for the presence of aberrant tissues such as striated muscle in the central nervous system. 展开 ...
Meningiomas arising from the lining of the central nervous system are the most common primary intracranial tumors1. Meningiomas are thought to form from derivatives of the neural crest2, a multipotent embryonic cell population that exhibits remarkable genetic and functional diversity mediated by conserved...
GATA binding protein 4, a transcription factor upregulated in malignant meningioma, caused increased cell viability by controlling the expression of the miR-497~195 cluster, resulting in increased Cyclin D1 expression. Accordingly, GATA-4 inhibition via the small-molecule inhibitor NSC140905 restored ...
along the sphenoid ridge, or in the vicinity of the optic chiasm; in addition to meningothelial meningioma, fibrous, transitional, metaplastic, psammomatous, secretory, clear cell, papillary, rhabdoid, chordoid, lymphoplasmocytic, angiomatous, microcystic, rhabdoid, atypical, and anaplastic varietie...
Single-cell RNA sequencing of seven non-tumor-associated human dura samples and six primary meningioma tumor samples (4 matched and 2 non-matched) was performed. Cell type identities, gene expression profiles, and T cell receptor expression were analyzed. Copy number variant (CNV) analysis was pe...
Preliminary Effect of Cyberknife Radiosurgery in the Treatment of 31 Patients with Advanced Non-small Cell Lung Cancer Background and objective Recently,Cyberknife is a new flame-less stereotactic radiation therapy tech-nology,which has several advantages,such as large dose... LV Yanling,Z Wang,X ...
A cytological diagnosis of spindle cell lesion of neural origin with the closest possibility of meningioma was rendered. Excision biopsy confirmed the diagnosis of ectopic parapharyngeal meningioma. It is important for clinicians and pathologists to be aware of this entity at the unusual site....