Despite affecting thousands of people worldwide, much remains unknown about this disease, and the development of systemic treatments is still far behind in comparison to other types of tumours. Therefore, forming 3D structures (spheroids and organoids) could facilitate research on the me...
"Glioblastoma is the most common type of malignant tumor in the brain," says Dr. Sherman. After diagnosis,treatmentusually starts with surgery. "The first step is to remove as much of it as you can," says Dr. Sherman. Treatments may slow the growth of cancer, but there is no cure for...
This retrospective study analyzes the prognostic factors, the effect of different methods of treatments, and the behavior of atypical meningiomas. The study comprised 44 patients who were given a diagnosis of atypical meningioma according to the 2007 World Health Organization classification in the period...
Following the indicated treatments, the cells were rinsed twice using PBS and subsequently exposed to 5 μM DCFH-DA for a duration of 30 min at a temperature 37 °C without light. An equal number of cells were rinsed and then suspended in culture medium for further analysis using a flow ...
Meningiomas are the most common primary intracranial tumors. There are no effective medical therapies for meningioma patients, and new treatments have been encumbered by limited understanding of meningioma biology. Here, we use DNA methylation profiling on 565 meningiomas integrated with genetic, transcript...
When comparing original tumor to xenograft and normal brain tissue, the authors found high correlation between original tumor and xenograft genes. Moreover, a large study involving several hundred xenograft cancer models of many types showed no enrichment of cancer-related genes in xenografts and ...
Meningiomas are the most common primary intracranial brain tumor, and have a heterogeneous biology and an unmet need for targeted treatment options. Existing treatments for meningiomas are limited to surgery, radiotherapy, or a combination of these depending on clinical and histopathological features. Tr...
This included patients with relapse after surgery, large tumors or complexly growing tumor. Thus the treating physician is frequently faced with the dilemma to spare as much of critical normal tissue without missing gross tumor. The use of highly conformal treatments including IMRT even increases ...
(anaplastic), account for approximately one-third of cases and often recur despite optimal management4,5. Systemic and molecular therapies for meningioma patients remain investigational, and new treatments have been encumbered by the lack of relevant model systems and limited understanding of meningioma ...
Most individuals received one course of radiation, but B9% of the patients received X2 treatments (Werner et al, 1968). A subgroup of children who were treated in Israel, including a group of 10 842 irradiated individuals with two matched non- exposed population and sibling groups (referred ...