在干细胞移植中,患者的干细胞通常会首先采集并冷冻保存。接下来,患者会接受高剂量的美法仑/马法兰化疗,这个过程被称为"预处理"或"条件化"(conditioning)。美法仑/马法兰的作用是通过杀死体内的白血病或淋巴瘤细胞,清除患者骨髓中的异常细胞,为后续的干细胞移植创造一个相对干净的环境。 一旦预处理完成,患者的之前...
There is described the use of idarubicin at dosages of from 12 to 17 mg/m2 days 1-3 i.v. as continuous infusion, followed by Melphalan, 180 mg/m2, day 5, as a conditioning regimen for the treatment of cancers responsive to idarubicin such as multiple myeloma (MM), non Hodgkin ...
BACKGROUND AND OBJECTIVES: Since a study published in 2002 showed a survival advantage of melphalan-only conditioning for stem cell transplantation (HSCT) over melphalan-total body irradiation (mel-TBI) in patients with multiple myeloma (MM), most centers abandoned mel-TBI. Mel-TBI causes more ea...
High-dose idarubicine, busulphan and melphalan as conditioning for autologous blood stem cell transplantation in multiple myeloma. A feasibility study. Extensive studies have tested the clinical impact of double and triple sequential transplants as front-line therapy in MM, following the suggestion tha...
Propylene glycol-free melphalan Conditioning Autologous hematopoietic cell transplantation Multiple myeloma Light chain amyloidosis Multiple myeloma (MM) is the second most common hematologic malignancy, accounting for 1% to 1.8% of all cancers, with the majority of diagnoses being made in patients 65 yea...
Use of propylene glycol-free melphalan conditioning in light-chain amyloidosis patients undergoing autologous hematopoietic cell transplantation is well tolerated and effectiveCytokine-based mobilization in light chain (AL ) amyloidosis is frequently complicated by fluid overload, weight gain, cardiac ...
Sinusoidal obstruction syndrome;/veno-occlusive disease after high-dose intravenous busulfan;/melphalan conditioning therapy in high-risk Ewing Sarcoma Sinusoidal obstruction syndrome;/veno-occlusive disease after high-dose intravenous busulfan;/melphalan conditioning therapy in high-risk Ewing Sarcoma... ...
Oral mucositis (OM) is one of the most frequent adverse events of high-dose conditioning chemotherapy with melphalan prior to autologous hematopoietic stem cell transplantation (AHSCT). It significantly reduces the patients’ quality of life. One of the preventive strategies for OM is cryotherapy. ...
Melphalan and purine analog-containing preparative regimens: reduced-intensity conditioning for patients with hematologic malignanci... Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplant... ...
We have evaluated the outcome of allogeneic haemopoietic stem cell transplantation for multiple myeloma using a conditioning regimen comprising fractionated total body irradiation and high-dose melphalan (110 mg/m2). The study comprised 25 patients (median age 49 years) who had been transplanted by ei...