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Solid cancers metastasize to bone by a multistep process that involves interactions between tumor cells and normal host cells. Some tumors, most notably breast and prostate carcinomas, grow avidly in bone because the bone microenvironment provides a favorable soil. In the case of breast carcinoma,...
Bone metastasis in prostate cancer: molecular and cellular mechanisms (Review). Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. The bony metastasis is incurable and contr... L Ye,H Kynaston,W Jiang - 《International Journal of ...
Key words : bone metastasis, cancer therapy, micrometastasis, prostate cancer, survival factors Plan Systematic spread of the tumour cells: the dynamic journey to the bones Colonizing the bone: the orchestration of an osteoclastic bone resorption Sheltering inside the bone marrow: domination of the ...
As one of the most common metastatic sites of malignancies, bone has a unique microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated capillaries in the bone, bone matrix, and bone cells, including osteoblasts and osteoc
In this review, we present evidence that non-coding RNAs (ncRNAs) such as long ncRNAs, microRNAs, and circular RNAs are emerging as master regulators of bone metastasis formation. We highlight potential opportunities for the therapeutic targeting of ncRNAs. Furthermore, we discuss the possibility ...
IJMS, Vol. 17, Pages 1415: Molecular Mechanisms of Bone Metastasis: Which Targets Came from the Bench to the Bedside? Casimiro S, Ferreira AR, Mansinho A, Alho I, Costa L: Molecular Mechanisms of Bone Metastasis: Which Targets Came from the Bench to the Bedside? Int... Casimiro,Sandra...
osteoblastic metastasisbreast cancerprostate cancerparathyroid hormone-related proteinendothelin-1adrenomedullinRANK ligandosteoprotegerinbisphosphonate.Purpose of review: Human tumor cells inoculated into the arterial circulation of immunocompromised mice can reproducibly cause bone metastases resembling those seen in ...
The metastasis of cancer to bone is a frequent outcome of common malignancies and is often associated with significant morbidity due to osteolysis. Bone me
As one of the most common metastatic sites of malignancies, bone has a unique microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated capillaries in the bone, bone matrix, and bone cells, including osteoblasts and osteoc