With this attention, comes the need to better understand both the mechanisms of action of β-lactams against M. tuberculosis as well as possible mechanisms of resistance, within the context of what is known about the β-lactam action in other bacteria. M. tuberculosis has two major mechanisms ...
With this attention, comes the need to better understand both the mechanisms of action of b-lactams against M. tuberculosis as well as possible mechanisms of resistance, within the context of what is known about the b-lactam action in other bacteria. M. tuberculosis has two major mechanisms ...
Newer mechanismsof resistance to β-lactam antibiotics in gram-negative bacteria. J: Piddock LJV, Wise R: Antimicrob Chemother 16:279–282, 1985cervical cancercervixcorrectional institutionsfollow uphuman diseasesneoplasmswomenAudet-Lapointe P.P, Audet-Lapointe...
However, bacteria have gained resistance mechanisms to overcome all major classes of b-lactam antibiotics to date. In this chapter, we will address the major mechanisms of bacterial resistance to the b-lactams and highlight some of the recent advances in circumventing this resistance. 展开 ...
Mlynarczyk A, Mlynarczyk B, Kmera-Muszynska M, Majewski S, Mlynarczyk G (2009) Mechanisms of the resistance and tolerance to beta-lactam and glycopeptide antibiotics in pathogenic Gram-positive cocci. Mini Rev Med Chem 9: 1527-1537....
Although it has been known for many years that beta-lactam antibiotics inhibit the synthesis of peptidoglycan, it was the phenomenon of tolerance which allowed elucidation of the mode of action of beta-lactam antibiotics particularly with respect to the lysis of the bacteria. By studying tolerant ...
Most bacteria in nature exist in aggregated communities known as biofilms, and cells within a biofilm demonstrate major physiological changes compared to their planktonic counterparts. Biofilms are associated with many different types of infections which
Patterns and mechanisms of resistance to -lactams and -lactamase inhibitors in uropathogenic Escherichia coli isolated from dogs in PortugalLittle is known about -lactam and -lactamase inhibitor susceptibilities of uropathogenic Escherichia coli isolates from animals. Seventy-two isolates collected from ...
The bacterial cell may have a membrane pump capable of pumping a class or several classes of antibacterial agents back out of the cell. Other mechanisms of drug resistance include destruction of beta-lactam ring by -lactamases, impermeability of the drug into the bacterial cell wall, alteration ...
The burden of multidrug resistance in Gram-negative bacilli (GNB) now represents a daily issue for the management of antimicrobial therapy in intensive care unit (ICU) patients. In Enterobacteriaceae, the dramatic increase in the rates of resistance to t