Origin licensing ensures precise once per cell cycle replication in eukaryotic cells. The Origin Recognition Complex, Cdc6 and Cdt1 load Mcm2-7 helicase (MCM) into a double hexamer, bound around duplex DNA. The complex formed by ORC-Cdc6 bound to duplex
Costas C, de la Paz Sanchez M, Stroud H, Yu Y, Oliveros JC, Feng S, Benguria A, Lopez-Vidriero I, Zhang X, Solano R, Jacobsen SE, Gutierrez C (2011) Genome-wide mapping of Arabidopsis thaliana origins of DNA replication and their associated epigenetic marks. Nat Struct Mol Biol 18...
Surface water 0.5–450 y = 1.987x + 17.06 0.9934 0.14 0.47 -17.8 Fig. 4 presents the typical chromatograms of spiked surface water samples superimposed with unspiked surface water, spiked ultrapure and procedure blank samples obtained via the UA-D-µ-SPE/HPLC-DAD method. As shown in Fig....
Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-de
Circular RNAs (CircRNA) have emerged as an interest of research in recent years due to its regulatory role in various kinds of cancers of human body. Esophageal squamous cell carcinoma (ESCC) is one of the major disease subtype in Asian countries, includ
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26. Zhou H, Xiong Y, Zhang G, Liu Z, Li L, Hou S, et al. Elevated expression of minichromosome maintenance 3 indicates poor outcomes and promotes G1/S cell cycle progression, proliferation, migration and invasion in colorectal cancer. Biosci Rep. 2020;40(7). https://doi.org/10.1042/...
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Nimisha, N.P., Narendranath, S.B., Ganesh, V.et al.Ru Loaded MCM-22: A Potential Catalyst for the Isomerization and Cracking of 1-Dodecene.Catal Lett154, 1694–1714 (2024). https://doi.org/10.1007/s10562-023-04407-x Download citation...
De novomotif finding was carried out separately on ORC-MCM2, ORC-only, and MCM2-only sites using BioProspector with the recommended significance level of p = 2.9 × 10-7(Z value = 5) [63]. A motif length of 17 bp was chosen based on the following prior information: (1) Ade novo...