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Download PDFs Help Help AplidinradiationoxygenationBystander effectsPurpose: Aplidin (plitidespin) is a novel cyclic depsipeptide, currently in Phase II clinical trials for solid and hematologic malignancies. We examined the effects of oxygen on the cytotoxicity of Aplidin and the interactions between ...
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27 articles dealing with evaluation of the association ofMBL2polymorphisms and TB risk were screened. After careful reading of the full-text of all the screened articles, 5 studies were disqualified (1 study was omitted as it reported expression analysis; 1 study was excluded due to lack of pa...
9 MBLAC2 inhibition and knockdown effects on proteome and lipidome. siRNA-mediated MBLAC2 knockdown does not lead to major changes of intracellular protein levels. Volcano plots display the difference in protein abundances of HEK293 cells after DMSO treatment of transfection with MBLAC2-directed si...
Thus, the SNP prediction showed a deleterious effect, which indicated that the substitution of the amino acid would lead to adverse effects on the function of the protein [24]. Moreover, the PolyPhen-2 tool revealed a score of 1.00 using the HumVar model, which designated the variant as a...
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