Anti-inflammatory effects of proanthocyanidin-rich red rice extract via suppression of MAPK, AP-1 and NF-κB pathways in Raw 264.7 macrophages. Nutr Res Pract 2016; 10.Limtrakul, P., Yodkeeree, S., Pitchakarn, P., & Punfa, W. (2016). Anti- inflammatory effects of proanthocyanidin-rich...
NF-κB nuclear factor-kappa B 核因子-κB IKK-β nuclear factor kappa-B kinase subunit 核因子-κB 激酶亚基β beta IκB inhibitory kappa B 核因子-κB 抑制蛋白 IL-1β interleukin-1β 白细胞介素-1β IL-6 interleukin-6 白细胞介素-6 IL-8 interleukin-8 白细胞介素-8 MCP-1 monocyte ...
Exposing rat PMVECs to simulated non-hypoxic IR caused lipid peroxidation, inflammation and apoptosis, which required MAPK-mediated NF-κB and AP-1 activation and distinct regulation of MAPKs by these 2 transcription factors. This model could be used to uncouple mechanisms of IR and evaluate ...
Ju KD, Yu JH, Kim H et al (2006) Role of mitogen-activated protein kinases, NF-kappaB, and AP-1 on cerulein-induced IL-8 expression in pancreatic acinar cells. Ann N Y Acad Sci 1090:368–374. https://doi.org/10.1196/annals.1378.040 Article CAS PubMed Google Scholar Hardman J, Ja...
It has been reported that COX-2 is regulated by mitogen-activated protein kinase (MAPK) and/or nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κ B) signalings in various types of cells and tissues, including airway cells11,12. Interestingly, aulpsroegbueleantiornepoof...
HBD3-3 was able to downregulate the nuclear factor-kappa B (NF-κB)-dependent inflammatory response via direct suppression of the phosphorylated-nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha (IκBα) degradation and downregulation of the p65 unit of ...
Supplementary Figure 1 Inhibition of the NF-κB and MAPK pathways and cell death in primary cortical neurons following simulated ischemic conditions. (A and B). Representative immunoblots and quantification illustrating the effect of increasing concentrations (μM) of a NF-κB inhibitor (Bay-11-7082...
(tumor progression locus-2, also known as Cot and MP3K8) which is released from an inhibitory complex with NF-B1 p105 and ABIN-2 (A20-binding inhibitor of NF-kappaβ activation) to activate MEK1/MEK2 and ERK1/ERK2 but is not well understood in mechanism nor whether it also activates...
NF-κB and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH) Prostaglandins are known to play an important role in human labour and are used clinically to induce labour onset. Cytokines, e.g. interleukin 1 β (IL-1β... C V.,Allport,M D....
雨蛙素构建的SAP大鼠模型中,胰腺腺泡细胞内p38MAPK的磷酸化水平显著上升,同时伴有NF-κB的激活[21],NF-κB亚基的活化过程有p38MAPK信号转导通路的参与,NF-κB活化可导致更多的炎性介质释放,使得炎症进一步加重,导致级联瀑布效应,使得SAP严重程度加剧,进而为局部炎症向全身发展提供了契机。因此p38MAPK信号转导通路具有放...