Bone remodeling in the adult skeleton facilitates the removal and replacement of damaged and old bone to maintain bone quality. Tight coordination of bone resorption and bone formation during remodeling crucially maintains skeletal mass. Increasing evidence suggests that many cell types beyond osteoclasts ...
5,6 Interestingly, when macrophages were depleted from the healing sites, there was significant suppression of bone matrix deposition and bone mineralization.7 Furthermore, osteal macrophages located in the lining tissue of the bone surface support physiologic skeletal remodeling and anabolic actions of ...
The osteoclast is a physiological polykaryon and the major if not exclusive resorptive cell of bone. It participates in bone remodeling, repair, and growth and mobilization of mineral to meet homeostatic demands. Most importantly, osteoporosis, a disease endemic in Western society and Asia, is alwa...
An essential function of macrophages is to sanitize the cellular fragments produced by tissue remodeling and apoptosis, leading to cell death.9For these events, macrophages can sense danger signals over pattern recognition receptors (PRRs), consisting of TLRs and C-type lectin receptors (CLRs). Afte...
To ask questions about the role of macrophage phenotype in situ, phenotypically defined polarized macrophages can be derived ex vivo, from bone marrow aspirates and added back to mice, with or without prior depletion of macrophages. In the protocol presented here clodronate-containing liposomes, ...
TAMs contribute to tumour progression also by producing several factors which enhance neo-angiogenesis and the dissolution and remodeling of the interstitial matrix. Moreover TAMs are a source of potent immunosuppressive molecules, s...
Its main function is to transfer complex and variable mechanical stress from the muscle to the bone or between bones [1]. As the focal aperture point of stress, the enthesis is susceptible to traumatic lesions. The incidence of enthesis injury is increasing as the interest in sporting ...
1993 . Macrophages are required for cell death and tissue remodeling in the developing mouse eye . Cell 74 : 453 – 462 ... RA Lang,JM Bishop - 《Cell》 被引量: 625发表: 1993年 Cooperative phagocytes: resident microglia and bone marrow immigrants remove dead photoreceptors in retinal lesion...
Patients with advanced RA suffer from the loss of physical function and low quality of life7,8. Therefore, a rational therapeutic approach that can alleviate synovial inflammation and reverse bone erosion is urgently needed for the treatment of advanced RA. Macrophages and osteoclasts (OCs) have ...
Lack of TGFβ signaling in macrophages suppresses inflammatory, but not basal, osteoclastogenesis and bone resorption in vivo. Mechanistically, TGFβ priming reprograms the macrophage response to TNF by remodeling chromatin accessibility and histone modifications, and enables TNF to induce a previously ...