M1 macrophages mediate tissue damage and initiate the inflammatory response in the early stages of wound healing. M2 phenotype promotes wound healing via formation of a highly vascularized, cellular granulation tissue and scar tissues. The phenotype of polarized M1-M2 macrophage can, to some extent,...
Osteoblast differentiation is a vital process for fracture healing, and exosomes are nanosized membrane vesicles that can deliver therapeutic drugs easily and safely. Macrophages participate in the regulation of various biological processes in vivo, and macrophage-derived exosomes (MD-Exos) have recently...
Exosomes M2 macrophages Hydrogel microneedle Wound healing 1. Introduction In the last five decades, the prevalence of diabetes has rapidly increased worldwide, showing an almost 10-fold increase [1]. Chronic refractory wounds are one of the most common complications of diabetes, and they cause a...
OBJECTIVE: To discuss the role and molecular mechanisms of M2 macrophage-derived exosomes in the phenotypic regulation of microglia. MERHODS: (1) Bone marrow primary macrophages were extracted and then stimulated with 50 ng/mL interleukin 4 for 24 hours to promote macrophage M2-type polarization. ...
M2 macrophages are usually termed in the literature as anti-inflammatory and wound healing. Substantial progress has been made in elucidating the biology of M2 macrophages and their potential for clinical translation. In this review we discuss the current state of knowledge in M2 macrophage research ...
关键词:巨噬细胞极化;信号通路;骨再生;成骨;综述 Advances in the signaling pathway of M2 macrophages involved in bone regeneration Zhang Jie1, Tian Ai1, 2 1School of Stomatology, Guizhou Medical University, Guiyang 550001, Guizhou Province, China; 2Department of Restoration and Implant, Affiliated ...
In addition, macrophage colony-stimulating factor (M-CSF) significantly contributed to the activation of M2-polarized macrophages. Moreover, the results of in vitro wound healing, cell migration and tube formation assays further revealed the pro-angiogenic function of M2-polarized macrophage-like cells...
The role of macrophages in tissue repair has recently been high- lighted by work in wound healing, in which the switch from M1 to M2 macrophages is required for resolution of inflammation and physiologic wound healing (44). Other investigators have shown that MACs have the potential to release...
ConclusionCorilagin may affect the pathophysiological process of wound healing by inhibiting M2 macrophage polarization, affecting the subtype distribution of M2 macrophages, and promoting the expression of fibrinolysis-related cytokines. KEYWORDS: Corilagin;Macrophage;Wound healing Corresponding author: Luo Xiao...
Macrophages can promote angiogenesis and granulation tissue formation during wound healing and facilitate tissue regeneration by producing growth factors and interacting with stem cells.However, dysregulated macrophage activity has been implicated in the pathogenesis of several chronic inflammatory disorders, ...