et al. CD303 (BDCA-2) signals in plasmacytoid dendritic cells via a BCR-like signalosome involving Syk, Slp65 and PLCgamma2. Eur. J. Immunol. 37, 3564–3575 (2007). 26. Maeda, T. et al. A novel plasmacytoid dendritic cell line, CAL-1, established from a patient with blastic ...
Crosslinking of the B cell antigen receptor surface immunoglobulin induces tyrosine phosphorylation and activation of the Src family and Syk tyrosine protein kinases, tyrosine phosphorylation of phospholipase Cgamma2 (PLCgamma2) and increases in intracellular second messengers inositol phosphates and Ca2+....
A recent study found that combining a lack of Lyn with a lack of phospholipase beta 3 (PLCβ3) causes a chronic myelomonocytic leukaemia through reduced SHP-1 activity resulting in enhanced STAT5 phosphorylation [77]. Evidence is mounting that strongly implicates an important role for Lyn in ...
Association of p72syk with the src homology-2 (SH2) domains of PLCγ1 in B lymphocytes J Biol Chem, 270 (1995), p. 11806 View PDFView articleView in ScopusGoogle Scholar 25 N Hirasawa, A Scharenberg, H Yamamura, MA Beaven, J-P Kinet A requirement for Syk in the activation of the...
Wang YH, Fan L, Wang L, Zhang R, Zou ZJ, Fang C, et al. (2012) The expression levels of Lyn, Syk, PLCgamma2 and ERK in patients with chronic lymphocytic leukemia, and higher levels of Lyn associ- ate with a shorter treatment free survival. Leuk Lymphoma....