体内单克隆抗体抗小鼠 Ly6G/Ly6C(Gr-1)部分文献引用: in vivo depletion of Gr-1+ myeloid cells Bansal, S., et al. (2018). "IL-1 Signaling Prevents Alveolar Macrophage Depletion during Influenza and Streptococcus pneumoniae Coinfection" J Immunol 200(4): 1425-1433. ...
骨髓来源的抑制性细胞(Myeloid-derived suppressor cells，MDSCs)是骨髓来源的一群异质性细胞，是树突状细胞(dendritic cells，DCs)、巨噬细胞和(或)粒细胞的前体，具有显著抑制免疫细胞应答的能力。小鼠MDSCs的表型为CD11b+Gr-1+，分两个亚型:粒细胞样的MDSCs(CD11b+Ly6C-Ly6G+)和单核细胞样的MDSCs...
小鼠MDSC的免疫表型和功能试验 总MDSCs的特征是 CD11b 和 Gr-1 等髓系标志物的表达(Gr-1是 Ly6C 和 Ly6G 两种不同标记物的组合)。 单核细胞 MDSCs(M-MDSCs) 通常为CD11b+ Ly6C high Ly6G-,即表达高水平的 Ly6C、 低表达或不表达Ly6G。 多形核 MDSCs(PMN-MDSCs) 为CD11b+ Ly6C low Ly6G+ 细胞,...
Ly6G是细胞表面蛋白家族的成员，分子量在21-25kDa之间，对细胞信号传导和细胞粘附具有重要作用。在髓系细胞，如单核细胞、巨噬细胞、粒细胞和中性粒细胞的发育过程中，Ly6G的表达量有所不同。特别地，Ly6G在单核细胞发育过程中短暂表达，而在成熟粒细胞和外周血中性粒细胞中持续存在，这使其成为一种理想...
(IL) 7R+and granzyme B+T cells in the tumor microenvironment. Interestingly, we observed that Ly6GlowG-MDSC sharply decreased after fasting treatment, and the cell surface markers and protein mass spectrometry data showed ...
Ly6G - cells show distinct functionin mice with chronic inflammation or tumorburdenEva Källberg, Martin Stenström, David Liberg, Fredrik Ivars and Tomas Leanderson *AbstractBackground: S100A9 has been shown to be important for the function of so called Myeloid Derived SuppressorCells (MDSC). ...
产品名称 Mouse Ly6G/Ly6C (Gr-1) Antibody from BIO X CELL 产品货号 BE0075-25MG 产品价格 现货询价,电话:010-67529703 产品规格 25 mg 产品品牌 BIO X CELL 产品概述 产品详情 Edit   Antigenic Specificity Mouse Ly6G/Ly6C (Gr-1) Clone RB6-8C5 Host Species Rat Reactive Species mouse ...
Mouse granulocytes Reported Applications in vivodepletion of Gr-1+ myeloid cells Flow cytometry Immunohistochemistry (paraffin) Immunohistochemistry (frozen) Endotoxin <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay Purity >95% Determined by SDS-PAGE ...
Our data showed that ANG II contributed to CD11b+Ly6Chi (CD11b+Ly6GLy6C+) cells reprogramming into M1-like macrophage through Erk1/2 or p38/Stat3 pathway and the reprogramming M1-like cells promoted Th17 cells expansion; abrogation of ANG II-AT1R axis significantly ameliorated cardiac injury. ...
造血干细胞(Hematopoieticstemcells,HSCs)是各种血细胞的始祖细胞, 具有持续和重建造血的重要生理功能。骨髓微环境(Niche)作为适宜HSCs生 存的特定微环境,通过黏附分子和膜表面信号分子与HSCs直接接触或通过分 泌细胞因子等刺激HSCs中信号的活化,从而调节HSCs的自我更新、增殖、分 ...