LXR alphaAims: Macrophage-derived foam-cell formation plays a crucial role in the development of atherosclerosis, and liver X receptor alpha (LXR alpha) is a key regulator of lipid metabolism in macrophages. Homocysteine (Hcy) is an independent risk factor of atherosclerosis; however, the ...
Intracellular cholesterol efflux mediated by ABCA1 and ABCG1 helps to reduce lipid accumulation in foam cells. Related studies have shown that autophagy and mTOR are involved in cholesterol efflux, but the role of p62, an autophagy substrate protein, has not been evaluated....
We therefore investigated the effects of pioglitazone on ABCA1/G1 expression in vitro and ex vivo. METHODS: The effects of pioglitazone on ChE and ABCA1/G1 expressions in macrophages were assessed. Then, mRNA was quantified in macrophages when PPARgamma/LXR inhibition by siRNA or overexpression ...
Kuwanon G attenuates atherosclerosis by upregulation of LXRα-ABCA1/ABCG1 and inhibition of NFκB activity in macrophages. Toxicol. Appl. Pharmacol. 2018, 341, 56-63. [CrossRef] [PubMed]Liu, X. X., Zhang, X. W., Wang, K., Wang, X. Y., Ma, W. L., Cao, W., et al. (...
Here, we sought to investigate the effects of Sal B on the cholesterol efflux in THP-1 macrophages.Yue, JianmeiLi, BoJing, QingpingGuan, QingboBiochemical and Biophysical Research CommunicationsYue J, Li B, Jing Q, Guan Q: Salvianolic acid b accelerated abca1-dependent cholesterol efflux by ...